AP26375PU-N Spi-6 antibody

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0.1 mg / €390.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Mouse Spi-6

AP26375PU-N

Product Description for Spi-6

Rabbit anti Mouse Spi-6.
Presentation: Purified
Product is tested for Western blot / Immunoblot, Flow Cytometry.

Properties for Spi-6

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Cytoplasmic antiproteinase 3, PI-9, serpin B9
Presentation Purified
Reactivity Ms
Applications F, WB
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
O08797
Immunogen:
Recombinant GST-Spi-6
GeneID:
20723
Application Flow Cytometry: The typical starting working dilution is 1/50.           
Western blot: The typical starting working dilution is 1/50.
Background Spi-6 is expressed in dendritic cells, lymphocytes and specific cell types at immune-privileged sites. It inactivates granzyme B, a natural occurring inducer of programmed cell death. As such, Spi-6 functions as anti-apoptotic protein. In cytotxic T cells (CTL), Spi-6 is required to protect clonal bursts (expansion) from granzyme B induced cell death. However, it is not required for the development of memory cells. Expression of SPI-6 is of crucial importance in the escape of several tumors from a CTL response and is, therefore, a parameter that influences the feasibility of CTL-mediated immunotherapy of cancer.
Concentration 0.1 mg/ml
General Readings
  1. Zhang M, Byrne S, Liu N, Wang Y, Oxenius A, Ashton-Rickardt PG. Differential survival of cytotoxic T cells and memory cell precursors. J Immunol. 2007 Mar 15;178(6):3483-91. PubMed PMID: 17339443.
  2. Zhang M, Liu N, Park SM, Wang Y, Byrne S, Murmann AE, et al. Serine protease inhibitor 6-deficient mice have increased neutrophil immunity to Pseudomonas aeruginosa. J Immunol. 2007 Oct 1;179(7):4390-6. PubMed PMID: 17878334.
Storage

Store undiluted at 2-8°C.
Shelf life: one year from despatch.

Format
Purification:
Protein A Chromatography
Buffer System:
PBS
Preservatives:
0.02% Sodium Azide
Stabilizers:
0.1% BSA
State:
Liquid 0.2 µm filtered Ig fraction
Purified
Species Reactivity
Species reactivity (tested):
Mouse.
Specificity
Specificity:
The antibody recognizes Mouse Spi-6, also known as Serpin B9, a cytoplasmic serine protease inhibitor of ~42 kDa.
It shows no cross-reactivity with Mouse proteins related to Spi-6.
Gene ID 20723

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