NB400-104L SR-BI antibody

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0.1 ml / €310.00

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Rabbit anti Hamster, Mouse, Rat SR-BI


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  • NB400-104L
  • NB400-104L
  • NB400-104L

Product Description for SR-BI

Rabbit anti Hamster, Mouse, Rat SR-BI.
Presentation: HiLyte Fluor™ 488
Product is tested for Frozen Sections, Immunoprecipitation, Western blot / Immunoblot.

Properties for SR-BI

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation HiLyte Fluor™ 488
Reactivity Hst, Ms, Rt
Applications C, IP, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

A C-terminal peptide containing residues from mouse Scavenger Receptor-BI (within residues 450-509).
Application immunohistochemistry , immunoprecipitation , Western Blot 1:1000 -1:5000
Background High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
Concentration 1.78 mg/ml
General Readings
  1. Hullinger TG, Panek RL, Xu X, Karathanasis SK. p21-activated kinase-1 (PAK1) inhibition of the human scavenger receptor class B, type I promoter in macrophages is independent of PAK1 kinase activity, but requires the GTPase-binding domain. J Biol Chem. 2001 Dec 14;276(50):46807-14. Epub 2001 Oct 3. PubMed PMID: 11585816.
  2. Witt W, Kolleck I, Fechner H, Sinha P, Rüstow B. Regulation by vitamin E of the scavenger receptor BI in rat liver and HepG2 cells. J Lipid Res. 2000 Dec;41(12):2009-16. PubMed PMID: 11108734.
  3. Goti, D., et al. Effects of lipoprotein lipase on uptake and transcytosis of low density lipoprotein (LDL) and LDL-associated alpha-Tocopherol in a porcine in vitro blood-brain barrier model. JBC Papers in Press. Published on May 24, 2002 as Manuscript M203989200.
  4. Thomàs-Moyà E, Gianotti M, Proenza AM, Lladó I. The age-related paraoxonase 1 response is altered by long-term caloric restriction in male and female rats. J Lipid Res. 2006 Sep;47(9):2042-8. Epub 2006 Jun 30. PubMed PMID: 16816326.
  5. Timmers, C., Sharma, N., Opavsky, R., Maiti, B., Wu, L., Wu, J., Orringer, D., Trikha, P., Saavedra, H. I., and Leone, G. (2006) E2f1-3 Control E2F-target Expression and Cellular Proliferation via a p53-dependent Negative Feedback Loop, MCB.02147-02105.
  6. Timmers C, Sharma N, Opavsky R, Maiti B, Wu L, Wu J, et al. E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop. Mol Cell Biol. 2007 Jan;27(1):65-78. PubMed PMID: 17167174. (Free PMC Article available, 7 images available)
  7. Wadsack C, Tabano S, Maier A, Hiden U, Alvino G, Cozzi V, et al. Intrauterine growth restriction is associated with alterations in placental lipoprotein receptors and maternal lipoprotein composition. Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E476-84. Epub 2006 Sep 26. PubMed PMID: 17003234.
  8. Yesilaltay A, Morales MG, Amigo L, Zanlungo S, Rigotti A, Karackattu SL, et al. Effects of hepatic expression of the high-density lipoprotein receptor SR-BI on lipoprotein metabolism and female fertility. Endocrinology. 2006 Apr;147(4):1577-88. Epub 2006 Jan 12. PubMed PMID: 16410302.
  9. Zhang C, Yin W, Liao D, Huang L, Tang C, Tsutsumi K, et al. NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs. J Lipid Res. 2006 Sep;47(9):2055-63. Epub 2006 Jun 28. PubMed PMID: 16807312.
  10. Zhong J, Gastaminza P, Chung J, Stamataki Z, Isogawa M, Cheng G, et al. Persistent hepatitis C virus infection in vitro: coevolution of virus and host. J Virol. 2006 Nov;80(22):11082-93. Epub 2006 Sep 6. PubMed PMID: 16956932. (Free PMC Article available, 7 images available)
  11. Akpovi CD, Yoon SR, Vitale ML, Pelletier RM. The predominance of one of the SR-BI isoforms is associated with increased esterified cholesterol levels not apoptosis in mink testis. J Lipid Res. 2006 Oct;47(10):2233-47. Epub 2006 Jul 21. PubMed PMID: 16861621.
  12. Azhar S, Medicherla S, Shen WJ, Fujioka Y, Fong LG, Reaven E, et al. LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells. J Lipid Res. 2006 Nov;47(11):2538-50. Epub 2006 Aug 23. PubMed PMID: 16929031. (Free PMC Article available, 8 images available)
  13. Sané AT, Sinnett D, Delvin E, Bendayan M, Marcil V, Ménard D, et al. Localization and role of NPC1L1 in cholesterol absorption in human intestine. J Lipid Res. 2006 Oct;47(10):2112-20. Epub 2006 Jul 7. PubMed PMID: 16829661.
Storage Store at 4C. Do not freeze.
HiLyte Fluor™ 488
Affinity purified
Buffer System:
Tris-citrate/phosphate [pH 7-8] buffer.
Affinity purified
Reacts with mouse, rat, mink and hamster SR-BI and the long form of human CLA-I.

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