discontinued

GTX80810 SRC-1 antibody

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0.1 ml / €400.00

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Mouse anti Human, Mouse SRC-1 1135/H4

GTX80810

Product Description for SRC-1

Mouse anti Human, Mouse SRC-1 1135/H4.
Product is tested for Immunoprecipitation, Western blot / Immunoblot, Paraffin Sections.

Properties for SRC-1

Product Category Primary Antibodies
Quantity 0.1 ml
Reactivity Hu, Ms
Applications IP, P, WB
Clonality Monoclonal
Clone 1135/H4
Host Mouse
Isotype IgG1
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide corresponding to amino acids 477-947 from human SRC-1.
Application IHC-P, IP, WB
Background Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcriptional activity of the nuclear receptor with which they associate. One such coactivator is Steroid Receptor Coactivator-1 (SRC-1).SRC-1 has been shown to interact with and stimulate the transcriptional activity of estrogen, progesterone, retinoic acid, thyroid and glucocorticoid receptors, as well as retinoic X receptor (RXR) in a ligand dependent manner. The amino terminal region of SRC-1 contains a PAS-A-basic helix-loop-helix homology domain which has previously been shown to be dimerization domains in other nuclear transcription factors including the aryl hydrocarbon (Ah) receptor and its heterodimerization partner, ARNT. The carboxy-terminal region of SRC-1 has been shown to possess histone acetyltransferase activity specific primarily for histones H3 & H4.
Concentration 1 mg/ml
Storage -20
Format
State:
100 ul of purified mouse IgG1 (1 mg/ml) in PBS containing 1 mg/ml BSA and 0.05% sodium azide.
Specificity
Specificity:
Human, Mouse, Non-human primate

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