NB100-78286 Src antibody

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Rabbit anti Human Src

Product Description for Src

Rabbit anti Human Src.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for Src

Product Category Primary Antibodies
Quantity 0.05 ml
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Modified peptide (IEDNEY*TARQG)
Application Western Blot
Background c-Src (proto-oncogene tyrosine-protein kinase Src) is a 60 kD tyrosine protein kinase family containing both SH2 and SH3 domains. c-Src is expressed at high levels in differentiated cells including neurons, platelets, macrophages, many tumors. c-Src is a lipid-modified signaling molecule (myristolyated) involved in cell-cell interactions, cell migration, and proliferation through the phosphorylation of many substrates including beta-catenin, paxillin, and vinculin. Phosphorylation of c-Src on Tyr-526 by Csk (c-Src kinase) represses activity; c-Sc is activated by phospholipase D, insulin-like growth factor receptor, EGF-receptor, fibroblast growth factor receptor, and prolactin receptor binding. c-Src has been shown to be phosphorylated on multiple sites and to interact with polyoma virus middle T antigen, PYK2, HSP72, and caveolin. The Poly6055 antibody recognizes human phosphorylated Src (Tyr419) and has been shown to be useful for Western blotting.
General Readings
  1. Cooper, J., et al., 1986. Science 231:1431. 2. Ahn, B., et al., 2003. Mol. Cell. Biol. 23:3103. 3. Kilkenny, D., et al., 2003. J. Biol. Chem. 278:17448.
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Immunogen affinity purified
Buffer System:
This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and
Immunogen affinity purified
Aff - Purified

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