NB120-24789 Src antibody

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Rabbit anti Human, Mouse, Rat Src


Product Description for Src

Rabbit anti Human, Mouse, Rat Src.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for Src

Product Category Primary Antibodies
Quantity 0.05 ml
Synonyms Schmidt Ruppin A2
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

c-Src (Tyr215) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 215 of human c-Src. This peptide sequence has homology to other Src kinase family members, such as hck, fyn, csk, and yes. Thus, this antibody may recognize other Src family members when phosphorylated on their conserved SH-2 domain tyrosine site.
Background c-Src was the first proto-oncogenic non-receptor tyrosine kinase characterized in human. The Src family is composed of nine members in vertebrates, including c-Src, Yes, Fgr, Yrk, Fyn, Lyn, Hck, Lck, and Blk. Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility, and adhesion. Src-family kinases contain an amino terminal cell membrane anchor followed by an SH3 domain and an SH2 domain. The activity of c-Src is regulated by tyrosine phosphorylation at multiple sites. Tyrosine 418 is autophosphorylated following c-Src activation. Tyrosine 215 in the SH-2 domain of c-Src is phosphorylated following growth factor receptor activation. Both Tyr215 and Tyr418 phosphorylation increases tyrosine kinase activity, while phosphorylation of Tyr529 downregulates c-Src kinase activity. Thus, tyrosine phosphorylation of c-Src is critical for regulating its kinase activity.
Immunogen affinity purified
Immunogen affinity purified
Aff - Purified
This antibody is reactive against human, mouse and rat. It has not been tested against other species.

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