NB120-4816 Src antibody

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Rabbit anti Human, Mouse Src


Product Description for Src

Rabbit anti Human, Mouse Src.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for Src

Product Category Primary Antibodies
Quantity 0.05 ml
Synonyms Schmidt Ruppin A2
Presentation Aff - Purified
Reactivity Hu, Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptide derived from the region of Src that contains tyrosine 418 (tyrosine 419 including the initiating methionine). The sequence is conserved in human, mouse, rat, chicken and frog.
Background Src (also known as pp60src) is a non-receptor tyrosine kinase involved in signal transduction in many biological systems and implicated in the development of human tumors. Tyrosine 418 is located in the catalytic domain and is one of the autophosphorylation sites. Full catalytic activity of Src requires phosphorylation of tyrosine 418 (tyrosine 414 on frog Src, tyrosine 416 on chicken Src, and tyrosine 424 on mouse Src). This region of Src is also highly conserved in all of the related Src-family kinases, and thus prior immunoprecipitation may be required to identify which Src family member is being activated.
General Readings This product has been used in:Haas M et al. Src-mediated inter-receptor cross-talk between the Na+/K+-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases. J Biol Chem 277:18694-702 (2002). PubMed PMID: 11907028
Bourguignon LY et al. CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration. J Biol Chem 276:7327-36 (2001). PubMed PMID: 11084024
Ushio-Fukai M et al. Cholesterol depletion inhibits epidermal growth factor receptor transactivation by angiotensin II in vascular smooth muscle cells: role of cholesterol-rich microdomains and focal adhesions in angiotensin II signaling. J Biol Chem 276:48269-75 (2001). PubMed PMID: 11585822
Watcharasit P et al. Src family kinase involvement in muscarinic receptor-induced tyrosine phosphorylation in differentiated SH-SY5Y cells. Neurochem Res 26:809-16 (2001). PubMed PMID: 11565612
Suter DM & Forscher P Transmission of growth cone traction force through apCAM-cytoskeletal linkages is regulated by Src family tyrosine kinase activity. J Cell Biol 155:427-38 (2001). PubMed PMID: 11673478
Kumar P et al. Soluble E-selectin induces monocyte chemotaxis through Src family tyrosine kinases. J Biol Chem 276:21039-45 (2001). PubMed PMID: 11274196
Thodeti CK et al. Leukotriene D(4) triggers an association between gbetagamma subunits and phospholipase C-gamma1 in intestinal epithelial cells. J Biol Chem 275:9849-53 (2000). PubMed PMID: 10734140
Owens DW et al. The catalytic activity of the Src family kinases is required to disrupt cadherin-dependent cell-cell contacts. Mol Biol Cell 11:51-64 (2000). PubMed PMID: 10637290
Sussman MA et al. Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1. J Clin Invest 105:875-86 (2000). PubMed PMID: 10749567
Sanna PP et al. A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus. Proc Natl Acad Sci U S A 97:8653-7 (2000). PubMed PMID: 10890901
Ma YC et al. Src tyrosine kinase is a novel direct effector of G proteins. Cell 102:635-46 (2000). PubMed PMID: 11007482
Immunogen affinity purified
Buffer System:
Preservative: 0.05% Sodium AzideConstituents: 50% Glycerol, PBS, 1mg/ml BSA. pH 7.3
Immunogen affinity purified
Aff - Purified
Cross-reacts with Human, Chicken and Mouse.Not yet tested in other species.

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