discontinued

GTX24817 Src (phospho Y529) antibody

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50 µl / €370.00

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Rabbit anti Chicken, Human, Mouse, Rat Src (phospho Y529)

GTX24817

Product Description for Src (phospho Y529)

Rabbit anti Chicken, Human, Mouse, Rat Src (phospho Y529).
Presentation: Aff - Purified
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for Src (phospho Y529)

Product Category Primary Antibodies
Quantity 50 µl
Presentation Aff - Purified
Reactivity Chk, Hu, Ms, Rt
Applications C, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide (Human) derived from the region of Src that contains tyrosine 529, based on the human sequence. The sequence is conserved in mouse (tyrosine 534), chicken (tyrosine 527) and frog (tyrosine 525).
Application IHC-Fr, WB
Background Src (also known as pp60src) is a non-receptor tyrosine kinase involved in signal transduction in many biological systems and implicated in the development of human tumors. Tyrosine 529 is located near the carboxyl terminus of Src and acts as a negative regulator, in that Src is held in the inactive form through an intramolecular interaction between the SH2 domain and the carboxyl terminus when tyrosine 529 is phosphorylated by Csk. This conformation blocks phosphorylation of the catalytic domain residue (tyrosine 418 in the human sequence), thereby preventing Src activation. When tyrosine 529 is dephosphorylated, tyrosine 418 can be maximally phosphorylatedleading to full activation.
Format
Purification:
Immunogen affinity purified
Buffer System:
Preservative: 0.05% Sodium Azide; Constituents: 50% Glycerol, PBS, 1mg/ml BSA. pH 7.3
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Specificity:
Cross-reacts with Human, Chicken, Mouse and Rat. Not yet tested in other species.

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