discontinued

GTX82865 SREBP 2 antibody

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0.1 mg / €380.00

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Rabbit anti Mouse, Rat SREBP 2

Product Description for SREBP 2

Rabbit anti Mouse, Rat SREBP 2.
Product is tested for Western blot / Immunoblot.

Properties for SREBP 2

Product Category Primary Antibodies
Quantity 0.1 mg
Reactivity Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide: A(843) I S W L Q G D D A A V R S H(857). GTX82865 immunizing peptide corresponds to amino acid residues 843-857 from rat SREBP 2. This sequence is identical in human and differs by 1 a.a. in mouse.
Application WB
Background Sterol regulatory element-binding proteins (SREBPs) are transcription factors that are members of the basic helix-loop-helix leucine zipper family of DNA binding proteins. Three isoforms have been identified in mammalian tissues that vary in structure, regulation, and function. SREBP-1a and SREBP-1c (originally cloned as ADD1) are protein products of alternative promoter usage of the SREBP-1 gene. The third isoform is transcribed from a different gene, SREBP-2.SREBPs are present as 120 kDa inactive precursors in the endoplasmic reticulum (ER) membrane. Upon activation, the SREBP protein is translocated to the Golgi and proteolytic cleavage occurs resulting in a mature transcriptionally active 60-78 kDa fragment.In liver and adipose tissues, SREBPs have a significant influence on lipid and cholesterol accumulation by inducing the transcription of genes involved in these processes. While SREBP-1 is thought to be more important in regulating the expression of genes involved in triglyceride synthesis and accumulation, SREBP-2 has been more closely linked to those involved in cholesterol synthesis and accumulation.
Storage -20
Format
State:
100 ug of epitope affinity purified rabbit IgG (1 mg/ml) in PBS containing 1 mg/ml BSA and 0.05% sodium azide.
Specificity
Specificity:
Mouse and rat, others not tested.

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