NB100-55862 ST2 antibody

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0.1 mg / €420.00

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Rabbit anti Mouse ST2


Product Description for ST2

Rabbit anti Mouse ST2.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for ST2

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Murine ST2 (NT) peptide.
Background ST2 is a member of a superfamily containing the interleukin-1 receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. ST2 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF. More recently, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor (TLR) 4 signaling and to maintain endotoxin tolerance. It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP.
Concentration 1 mg/ml
General Readings
  1. Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
  2. Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
  3. Lanahan A, Williams JB, Sanders LK, Nathans D. Growth factor-induced delayed early response genes. Mol Cell Biol. 1992 Sep;12(9):3919-29. PubMed PMID: 1508193. (Free PMC Article available)
  4. Sweet MJ, Leung BP, Kang D, Sogaard M, Schulz K, Trajkovic V, et al. A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression. J Immunol. 2001 Jun 1;166(11):6633-9. PubMed PMID: 11359817.
  5. Brint EK, Xu D, Liu H, Dunne A, McKenzie AN, O'Neill LA, et al. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol. 2004 Apr;5(4):373-9. Epub 2004 Mar 7. PubMed PMID: 15004556.
  6. Liew FY, Liu H, and Xu D. A novel regulator for IL-1 and Toll-like receptor 4. Immunol. Lett. 2005; 96:27-31.
Storage Store at 4C. Do not freeze.
Immunogen affinity purified
Buffer System:
PBS containing 0.02% sodium azide.
Immunogen affinity purified
Aff - Purified
Mouse. Not yet tested in other species.

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