GTX23343 StAR antibody

See related secondary antibodies

Search for all "StAR"

0.1 mg / €400.00

Quick Overview

Rabbit anti Human, Rat StAR


Product Description for StAR

Rabbit anti Human, Rat StAR.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot, Paraffin Sections.

Properties for StAR

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Recombinant full length protein.
Application IHC-P, WB
Background Steroid hormone biosynthesis is acutely regulated by pituitary trophic hormones and other steroidogenic stimuli. This regulation requires the synthesis of a protein whose function is to translocate cholesterol from the outer to the inner mitochondrial membrane in steroidogenic cells, the rate-limiting step in steroid hormone formation. The Steroidogenic Acute Regulatory (StAR) protein is an indispensable component in this process. StAR is expressed in steroidogenic tissues in response to agents that stimulate steroid production, and mutations in the StAR gene result in congenital lipoid adrenal hyperplasia, a disease in which steroid hormone biosynthesis is severely compromised. The mechanism by which StAR mediates cholesterol transfer in the mitochondria has not been fully characterized. However, the tertiary structure of the START domain of a StAR homolog has been solved, and identification of a cholesterol-binding hydrophobic tunnel within this domain raises the possibility that StAR acts as a cholesterol-shuttling protein.
Concentration 1 mg/ml
Storage Upon receipt - Keep as concentrated solution. Aliquot and store at -20
Immunogen affinity purified
Buffer System:
PBS, 1 mg/ml BSA, 0.05% sodium azide
Immunogen affinity purified
Aff - Purified
Cross-reacts with Human and Rat. Not yet tested in other species.

Accessory Products

  • LinkedIn