discontinued

SP5227P StAR antibody

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0.1 mg / €420.00

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Rabbit anti Human, Rat StAR

Product Description for StAR

Rabbit anti Human, Rat StAR.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot, Paraffin Sections.

Properties for StAR

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms AB3343, StARD1
Presentation Aff - Purified
Reactivity Hu, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Recombinant StAR protein
Application Immunohistochemistry on paraffin sections.
Western blot: 1/1,000. Detects an ~30 kDa protein (tested with rat adrenal gland tissue extracts).
Background Steroid hormone biosynthesis is acutely regulated by pituitary trophic hormones and other steroidogenic stimuli. This regulation requires the synthesis of a protein whose function is to translocate cholesterol from the outer to the inner mitochondrial membrane in steroidogenic cells, the rate-limiting step in steroid hormone formation. The steroidogenic acute regulatory (StAR) protein is an indispensable component in this process. StAR is expressed in steroidogenic tissues in response to agents that stimulate steroid production, and mutations in the StAR gene result in congenital lipoid adrenal hyperplasia, a disease in which steroid hormone biosynthesis is severely compromised. The mechanism by which StAR mediates cholesterol transfer in the mitochondria has not been fully characterized. However, the tertiary structure of the START domain of a StAR homolog has been solved, and identification of a cholesterol-binding hydrophobic tunnel within this domain raises the possibility that StAR acts as a cholesterol-shuttling protein.
Concentration 1.0 mg/ml
General Readings J. Biol. Chem. Jul 2006; 281: 21535-21545.
Endocrinology doi:10. 210/en. 2005-0567, Aug 2005.
Endocrinology Vol 145(3), 1227-1237, Mar 2004.
Endocrinology Vol 145(10), 4775-4780, Sept 2004.
Storage Store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography
Buffer System:
PBS containing 1 mg/ml BSA as stabilizer and 0.05% sodium azide as preservative
State:
Liquid IgG fraction
Aff - Purified
Specificity
Specificity:
SP5227P reats with steroidogenic acute regulatory (StAR) protein.
Species:
Human, rat.

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