SP6215P STEAP (14-28) antibody

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50 µg / €250.00

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Rabbit anti Human STEAP (14-28)

Product Description for STEAP (14-28)

Rabbit anti Human STEAP (14-28).
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for STEAP (14-28)

Product Category Primary Antibodies
Quantity 50 µg
Presentation Aff - Purified
Reactivity Hu
Applications E, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer AnaSpec

Datasheet Extract

Synthetic peptide corresponding to amino acids 14-28 of human STEAP
AA Sequence:
Application ELISA: 0.1 - 1.0 µg/ml.
Western blot: 0.5 - 2 µg/ml, detects a band of ~39 kDa.
Immunoprecipitation (recommended but not tested): 3.0 - 5.0 µg/extract from 10e7 cells.
Immunohistochemistry on frozen sections (recommended but not tested): 2.0-5.0 µg/ml.
Background Prostate cancer is the most frequently diagnosed cancer and is the second leading cause of cancer-related deaths in American men (1). Although the early serum detection of prostate-specific antigen (PSA) plays important roles on early diagnosis, it may not distinguish prostate cancer from benign diseases (2, 3). Recently, a novel protein, which contains 339 amino acids, named STEAP (six-transmembrane epithelial antigen of the prostate), was identified in advanced prostate cancer (4). STEAP is unique among the currently known prostate cancer markers because of its putative secondary structure, from which one may predict that it functions as a potential channel protein. STEAP is strongly expressed in advanced prostate cancer and some extent expression in other cancers, such as colon and ovarian cancer cell lines.
Concentration 0.2 mg/ml
General Readings
  1. Lalani EN et al (1997) Cancer Mestatasis Rev, 16. 29-66.
  2. Oesterling JE (1992) J. Am. Med Assoc. 267, 2236-2238.
  3. Van Iesel MP, et al (1995) Br J Urol. 76, 47-53.
  4. Hubert RS et al (1999) Proc. Natl. Acad. Sci. USA 96 (25), 14523-14528.
Storage Store the antibody undiluted at 4-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf life: one year from despatch.
Epitope affinity chromatography
Buffer System:
1x PBS (pH 7.4) containing 0.05 % sodium azide
Liquid Ig fraction
Aff - Purified
This antibody reacts with STEAP.

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