NB110-6010 Steroidogenic Factor 1 antibody

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Rabbit anti Mouse, Rat Steroidogenic Factor 1

Product Description for Steroidogenic Factor 1

Rabbit anti Mouse, Rat Steroidogenic Factor 1.
Presentation: Aff - Purified
Product is tested for Frozen Sections, ChIP assay, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot, Paraffin Sections.

Properties for Steroidogenic Factor 1

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Ms, Rt
Applications C, ChIP, ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Purified :SF-1 fusion protein corresponding to the ligand-binding domain. (The exact immunogen sequence is "commercially sensitive").
Application ChIP, IHC-Fr, IHC-P, IF, WB, ICC
Background Steroidogenic factor-1 (SF-1) is an orphan nuclear receptor involved in organ development and differentiation of the endocrine system. SF-1 has been shown to be essential for fetal development of the hypothalamus, pituitary gland, gonads, and the adrenal gland. SF-1 has been shown to promote transcriptional activity of many steroidogenic enzymes from the cytochrome P450 family.
SF-1 contains two activation function domains, designated AF1 and AF2, common to many nuclear steroid receptors which have been shown to be necessary for interaction with other nuclear receptors as well as coactivators and corepressors including steroid receptor coactivator-1 (SRC-1), glucocorticoid receptor interacting protein 1 (GRIP1), cAMP response element binding protein (CREB) binding protein (CBP) and silencing mediator of retinoid acid and thyroid hormone receptor (SMRT).
General Readings Endo., 144(8): 3598-3610, 2003.
Endocrinology May 2005 doi:10.1210/en.2004-1643
Endocrinology, doi:10.1210/me.2005-0199, Jan 2006
Endocrinology, Vol 144: 3598-3610, Aug 2003
Fron. Neuroendocrin. 20: 199-223, 1999.
Genes Develop., 8: 2302-2312, 1994.
Mol. Endocrin., 12: 290-301, 1998.
Immunogen affinity purified
Buffer System:
PBS, 1 mg/ml BSA.
Immunogen affinity purified
Aff - Purified

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