AM26067AC-N STRO-1 antibody

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0.1 mg / €290.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human STRO-1 STRO-1

Product Description for STRO-1

Mouse anti Human STRO-1 STRO-1.
Presentation: APC
Product is tested for Flow Cytometry.

Properties for STRO-1

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation APC
Reactivity Hu
Applications F
Clonality Monoclonal
Clone STRO-1
Host Mouse
Isotype IgM
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Human CD34 positive bone marrow cells.
Application Flow Cytometry.
Background STRO-1 is a cell surface antigen expressed by stromal elements in human bone marrow, identified by monoclonal antibody STRO-1. Approximately 10% of mononuclear cells, greater than 95% of which are nucleated erythroid precursors, are STRO-1 positive, whereas the CFU-GM (colony-forming unit granulocyte-macrophage), BFU-E (erythroid burst) and CFU-Mix (mixed colonies) committed progenitor cells are negative. CFU-F (fibroblast colony-forming cells) are present exclusively in the STRO-1 positive population. When plated under long-term bone marrow culture conditions, STRO-1 positive cells generate adherent cell layers containing multiple stromal cell types, including adipocytes, smooth muscle cells, osteoblasts, chondrocytes, and fibroblastic elements. In combination with glycophorin A, STRO-1 is a useful marker for identification of mesenchymal stem cells. STRO-1 and CD117 are markers for osteosarcoma cells.
Concentration 0.1 mg/ml
General Readings
  1. Simmons PJ, Torok-Storb B. Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood. 1991 Jul 1;78(1):55-62. PubMed PMID: 2070060.
  2. Seo BM, Miura M, Sonoyama W, Coppe C, Stanyon R, Shi S. Recovery of stem cells from cryopreserved periodontal ligament. J Dent Res. 2005 Oct;84(10):907-12. PubMed PMID: 16183789.
  3. Gronthos S, Zannettino AC, Hay SJ, Shi S, Graves SE, Kortesidis A, Simmons PJ: Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. J Cell Sci. 2003 May 1;116(Pt 9):1827-35.
  4. Stenderup K, Justesen J, Eriksen EF, Rattan SI, Kassem M. Number and proliferative capacity of osteogenic stem cells are maintained during aging and in patients with osteoporosis. J Bone Miner Res. 2001 Jun;16(6):1120-9. PubMed PMID: 11393789.
  5. Kaneko R, Akita H, Shimauchi H, Sasano Y. Immunohistochemical localization of the STRO-1 antigen in developing rat teeth by light microscopy and electron microscopy. J Electron Microsc (Tokyo). 2009 Dec;58(6):363-73. doi: 10.1093/jmicro/dfp029. Epub 2009 Jun 12. PubMed PMID: 19525367.
  6. Bensidhoum M, Chapel A, Francois S, Demarquay C, Mazurier C, Fouillard L, et al. Homing of in vitro expanded Stro-1- or Stro-1+ human mesenchymal stem cells into the NOD/SCID mouse and their role in supporting human CD34 cell engraftment. Blood. 2004 May 1;103(9):3313-9. Epub 2004 Jan 8. PubMed PMID: 14715641.
  7. Oyajobi BO, Lomri A, Hott M, Marie PJ. Isolation and characterization of human clonogenic osteoblast progenitors immunoselected from fetal bone marrow stroma using STRO-1 monoclonal antibody. J Bone Miner Res. 1999 Mar;14(3):351-61. PubMed PMID: 10027900.
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Format
Label:
Conjugated with cross-linked Allophycocyanin (APC) under optimum conditions.
APC
Purification:
Size Exclusion Chromatography
Buffer System:
Tris buffered saline (TBS)
Preservatives:
15 mM Sodium Azide
State:
Liquid purified Ig fraction
Species Reactivity
Species reactivity (tested):
Human.
Specificity
Specificity:
This antibody detects the cell surface antigen STRO-1 expressed by bone marrow mesenchymal stromal cells and nucleated erythroid precursors, but not by committed hematopoietic progenitors.

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