AM26067PU-N STRO-1 antibody

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0.1 mg / €310.00
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Quick Overview

Mouse anti Human STRO-1 STRO-1

Product Description for STRO-1

Mouse anti Human STRO-1 STRO-1.
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Flow Cytometry.

Properties for STRO-1

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu
Applications F, ICC/IF
Clonality Monoclonal
Clone STRO-1
Host Mouse
Isotype IgM
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Human CD34 positive bone marrow cells.
Application Flow Cytometry.
Background STRO-1 is a cell surface antigen expressed by stromal elements in human bone marrow, identified by monoclonal antibody STRO-1. Approximately 10% of mononuclear cells, greater than 95% of which are nucleated erythroid precursors, are STRO-1 positive, whereas the CFU-GM (colony-forming unit granulocyte-macrophage), BFU-E (erythroid burst) and CFU-Mix (mixed colonies) committed progenitor cells are negative. CFU-F (fibroblast colony-forming cells) are present exclusively in the STRO-1 positive population. When plated under long-term bone marrow culture conditions, STRO-1 positive cells generate adherent cell layers containing multiple stromal cell types, including adipocytes, smooth muscle cells, osteoblasts, chondrocytes, and fibroblastic elements. In combination with glycophorin A, STRO-1 is a useful marker for identification of mesenchymal stem cells. STRO-1 and CD117 are markers for osteosarcoma cells.
Concentration 1.0 mg/ml
General Readings
  1. Simmons PJ, Torok-Storb B. Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood. 1991 Jul 1;78(1):55-62. PubMed PMID: 2070060.
  2. Seo BM, Miura M, Sonoyama W, Coppe C, Stanyon R, Shi S. Recovery of stem cells from cryopreserved periodontal ligament. J Dent Res. 2005 Oct;84(10):907-12. PubMed PMID: 16183789.
  3. Gronthos S, Zannettino AC, Hay SJ, Shi S, Graves SE, Kortesidis A, et al. Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. J Cell Sci. 2003 May 1;116(Pt 9):1827-35. PubMed PMID: 12665563.
  4. Stenderup K, Justesen J, Eriksen EF, Rattan SI, Kassem M. Number and proliferative capacity of osteogenic stem cells are maintained during aging and in patients with osteoporosis. J Bone Miner Res. 2001 Jun;16(6):1120-9. PubMed PMID: 11393789.
  5. Kaneko R, Akita H, Shimauchi H, Sasano Y. Immunohistochemical localization of the STRO-1 antigen in developing rat teeth by light microscopy and electron microscopy. J Electron Microsc (Tokyo). 2009 Dec;58(6):363-73. doi: 10.1093/jmicro/dfp029. Epub 2009 Jun 12. PubMed PMID: 19525367.
  6. Bensidhoum M, Chapel A, Francois S, Demarquay C, Mazurier C, Fouillard L, et al. Homing of in vitro expanded Stro-1- or Stro-1+ human mesenchymal stem cells into the NOD/SCID mouse and their role in supporting human CD34 cell engraftment. Blood. 2004 May 1;103(9):3313-9. Epub 2004 Jan 8. PubMed PMID: 14715641.
  7. Oyajobi BO, Lomri A, Hott M, Marie PJ. Isolation and characterization of human clonogenic osteoblast progenitors immunoselected from fetal bone marrow stroma using STRO-1 monoclonal antibody. J Bone Miner Res. 1999 Mar;14(3):351-61. PubMed PMID: 10027900.
Storage Store undiluted at 2-8°C.
Shelf life: one year from despatch.
Precipitation Methods and Ion Exchange Chromatography
Buffer System:
Tris buffered saline (TBS), pH~8.0
15mM Sodium Azide
Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Aff - Purified
Species Reactivity
Species reactivity (tested):
This antibody recognizes the cell surface antigen STRO1 expressed by bone marrow mesenchymal stromal cells and nucleated erythroid precursors, but not by committed hematopoietic progenitors.

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