discontinued

AP11286PU-N SUMO / SMT3 (N-term) antibody

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0.1 mg / €335.00

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Rabbit anti C. elegans SUMO / SMT3

AP11286PU-N

Product Description for SUMO / SMT3

Rabbit anti C. elegans SUMO / SMT3.
Properties: (N-term)
Presentation: Purified

Properties for SUMO / SMT3

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms GMP1, PIC1, Small ubiquitin-related modifier, UBL1, Ubiquitin-like protein SMT3, smo-1
Presentation Purified
Reactivity Ce
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P55853
Immunogen:
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide from the N-terminal region of nematode SUMO.
GeneID:
266820
Property N-term
Add. information Predicted MW: 10222 Da
Application ELISA: 1/1,000.
Background Covalent attachment of one protein to another is one of the more prominent posttranslational modifications in respects to size and ubiquity ? to which eukaryotic proteins are subject. Ubiquitin is the most familiar of the protein modifiers and its activation and transfer to target proteins has been studied for over two decades. Recently a new group of ubiquitin-like (Ubl) proteins have come to light. One of the most intriguing of them is SUMO (small ubiquitin-like modifier, ~12kDa) also known as Sentrin. SUMO family has been described in vertebrates: SUMO-1 and the closest homologs SUMO-2 and SUMO-3. SUMO have been shown to bind and regulate mammalian SP-RINGs (such as Mdm2, PIAS and PML), RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, Drosophila Ttk69, Dorsal, CaMK, yeast Septins, and viral CMV-IE1/2, EBV-BZLF1, HPV/BPV-E1. These bindings implicate SUMO in the stabilization of the target proteins and/or their localization to subcellular complexes. SUMO research enters now an exciting phase with a promise to help understanding how cells orchestrate the complexities of rapidly regulating protein level and activity.
Caution This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Concentration 0.25 mg/ml
General Readings
  1. Fraser, A.G., et al., Nature 408(6810):325-330 (2000).
  2. Lapenta, V., et al., Genomics 40(2):362-366 (1997).
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Buffer System:
PBS containing 0.09% (W/V) Sodium Azide as preservative
State:
Liquid purified Ig fraction
Purified
Specificity
Specificity:
This antibody is specific to Nematode SUMO (N-term).
Gene ID 266820

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