discontinued

GTX15527 Survivin prediluted antibody

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7 ml / €340.00

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Rabbit anti Human, Mouse Survivin prediluted

GTX15527

Product Description for Survivin prediluted

Rabbit anti Human, Mouse Survivin prediluted.
Presentation: Aff - Purified
Product is tested for Paraffin Sections.

Properties for Survivin prediluted

Product Category Primary Antibodies
Quantity 7 ml
Presentation Aff - Purified
Reactivity Hu, Ms
Applications P
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) derived from the C terminus of human survivin.
Application IHC-P
Background Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2 / M phase of the cell cycle in a cycle regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin microtubule interactions results in loss of survivin's anti apoptosis function and increased caspase 3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2 / M phase. The over expression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.
Concentration ready-to-use
Storage Keep as concentrated solution and store at 4
Format
Purification:
Immunogen affinity purified
Buffer System:
PBS, pH 7.4 containing 1%BSA and 0.1% sodium azide
Purity:
Immunogen affinity purified
State:
Liquid - Prediluted
Aff - Purified
Specificity
Specificity:
Cross-reacts with Human and Mouse. Not yet tested in other species.

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