GTX15527 Survivin prediluted antibody

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7 ml / €340.00

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Rabbit anti Human, Mouse Survivin prediluted


Product Description for Survivin prediluted

Rabbit anti Human, Mouse Survivin prediluted.
Presentation: Aff - Purified
Product is tested for Paraffin Sections.

Properties for Survivin prediluted

Product Category Primary Antibodies
Quantity 7 ml
Presentation Aff - Purified
Reactivity Hu, Ms
Applications P
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) derived from the C terminus of human survivin.
Application IHC-P
Background Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2 / M phase of the cell cycle in a cycle regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin microtubule interactions results in loss of survivin's anti apoptosis function and increased caspase 3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2 / M phase. The over expression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.
Concentration ready-to-use
Storage Keep as concentrated solution and store at 4
Immunogen affinity purified
Buffer System:
PBS, pH 7.4 containing 1%BSA and 0.1% sodium azide
Immunogen affinity purified
Liquid - Prediluted
Aff - Purified
Cross-reacts with Human and Mouse. Not yet tested in other species.

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