TA306581 Syntaphilin / SNPH antibody

Rabbit Polyclonal Syntaphilin Antibody

See related secondary antibodies

Search for all "Syntaphilin / SNPH"

0.1 mg / €325.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Mouse, Rat Syntaphilin / SNPH

TA306581

More Views

  • TA306581
  • TA306581

Product Description for Syntaphilin / SNPH

Rabbit anti Human, Mouse, Rat Syntaphilin / SNPH.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for Syntaphilin / SNPH

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms KIAA0374
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
O15079
Immunogen:
Syntaphilin antibody was raised against a 18 amino acid peptide from near the amino terminus of human Syntaphilin.
GeneID:
9751
Add. information Blocking peptide available: AP30849CP-N
Application ELISA.
Western blot: 2 – 4 μg/ml.
Immunohistochemistry on paraffin sections.
Background Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function. Despite its predicted molecular weight, Syntaphilin usually migrates at higher molecular weight in SDS-PAGE. Multiple isoforms are known to exist.
General Readings
  1. Lao G, Scheuss V, Gerwin CM, Su Q, Mochida S, Rettig J, et al. Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly. Neuron. 2000 Jan;25(1):191-201. PubMed PMID: 10707983.
  2. Sørensen JB. SNARE complexes prepare for membrane fusion. Trends Neurosci. 2005 Sep;28(9):453-5. PubMed PMID: 15996765.
  3. Das S, Gerwin C, Sheng ZH. Syntaphilin binds to dynamin-1 and inhibits dynamin-dependent endocytosis. J Biol Chem. 2003 Oct 17;278(42):41221-6. Epub 2003 Aug 1. PubMed PMID: 12896979.
  4. Kang JS, Tian JH, Pan PY, Zald P, Li C, Deng C, et al. Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation. Cell. 2008 Jan 11;132(1):137-48. doi: 10.1016/j.cell.2007.11.024. PubMed PMID: 18191227. (Free PMC Article available, 7 images available)
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Peptide affinity chromatography
Buffer System:
PBS containing 0.02% sodium azide
State:
Liquid Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, mouse, rat
Specificity
Specificity:
This antibody detects Syntaphilin.

Accessory Products

Proteins and/or Positive Controls

Proteins for Syntaphilin / SNPH (1 products)

Catalog No. Species Pres. Purity   Source  

Syntaphilin / SNPH

Syntaphilin / SNPH Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Positive controls for Syntaphilin / SNPH (1 products)

Catalog No. Species Pres. Purity   Source  

SNPH overexpression lysate

SNPH overexpression lysate
0.1 mg / €280.00
  OriGene Technologies, Inc.
  • LinkedIn