SM7094 Syntaxin 13 antibody

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Mouse anti Canine, Hamster, Mouse, Rat Syntaxin 13

Product Description for Syntaxin 13

Mouse anti Canine, Hamster, Mouse, Rat Syntaxin 13.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for Syntaxin 13

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Early Endosome Marker
Presentation Purified
Reactivity Can, Hst, Ms, Rt
Applications WB
Clonality Polyclonal
Host Mouse
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Recombinant cytoplasmic domain of rat syntaxin 13 (1)
Application Western blot analysis: 0.1 µg/ml.
Recommended Positive Control: mouse or rat brain.
Background Syntaxin 13 is an integral membrane protein that belongs to the t-SNARE family, a group of proteins involved in protein transport (1). Confocal immunofluoresence and electron microscopy studies have shown that syntaxin 13 is primarily localized to tubular early and recycling endosomes, where it colocalizes with transferrin receptor, and it is also localized in endosomal vacuoles (2). Syntaxin 13 has been found to be expressed in all tissues, with higher levels of the protein found in brain, lung, spleen, thymus and testes (2). Immunoprecipitation studies show that syntaxin 13 complexes with beta-SNAP, VAMP2/3, and SNAP25 (2). The binding of this complex to alpha-SNAP and NSF is terminated in the presence of ATP (2). These results suggest that syntaxin 13 is a SNARE protein which mediates the recycling protein flow through tubulo-vesicular recycling endosomes (2).
Concentration 1.0 mg/ml
General Readings
  1. Advani, R.J., et al. (1998) J. Biol. Chem. 273: 10317-10324.
  2. Prekeris, R., Klumperman, J., Chen, Y.A. and Scheller, R.H. (1998) J. Cell Biol. 143: 957-971.
  3. Huang, L; Kuo, YM; Gitschier, J; (1999) Nat Genet 23(3): 329-332.
Storage Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Centrifuge vial before opening.
Shelf life: one year from despatch.
Protein G Chromatography
Buffer System:
PBS, 0.1 mM PMSF and 50 % glycerol
Liquid Ig fraction
Identifies recombinant rat syntaxin 13 and detects an ~38 kDa protein in immunoblots. Additional bands of 27 and 37 kDa may also be recognized in these lysates, and are believed to correspond to degradation products of syntaxin 13.
Mouse, Rat, Dog, Hamster.

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