NB120-3309 Synuclein antibody

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Mouse anti Human Synuclein syn204


Product Description for Synuclein

Mouse anti Human Synuclein syn204.
Product is tested for Western blot / Immunoblot.

Properties for Synuclein

Product Category Primary Antibodies
Quantity 0.5 ml
Reactivity Hu
Applications WB
Clonality Monoclonal
Clone syn204
Host Mouse
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Recombinant full length protein (Human).
Background Synnuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson?s (PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.
General Readings General / background references:Giasson BI et al. A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease. J Neurosci Res 59:528-33 (2000). PubMed PMID: 10679792
Storage Store at 4C. Do not freeze.
Buffer System:
10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Cross-reacts with Human.Does not cross-react with Rat or Mouse.Not yet tested in other species.

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