NB100-77506 T Cell Receptor gamma/delta antibody

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Hamster anti Mouse T Cell Receptor gamma/delta UC7-13D5


Product Description for T Cell Receptor gamma/delta

Hamster anti Mouse T Cell Receptor gamma/delta UC7-13D5.
Presentation: FITC
Product is tested for Flow Cytometry.

Properties for T Cell Receptor gamma/delta

Product Category Primary Antibodies
Quantity 0.5 mg
Presentation FITC
Reactivity Ms
Applications F
Clonality Monoclonal
Clone UC7-13D5
Host Hamster
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Application flow cytometry / FACS analysis
Background T cell receptor (TCR) is a heterodimer consisting of an alpha and a beta chain (TCR alpha/ beta) or a gamma and a delta chain (TCR gamma/ delta). TCR gamma/ delta belongs to the immunoglobulin superfamily, involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. The gamma/ delta TCR associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most gamma/ delta T cells are CD4-/CD8-, some are CD8+. T cells expressing the gamma/ delta TCR have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that gamma/ delta T cells also play a principal role in antigen presentation. Immobilized UC7-13D5 antibody has been reported to activate gamma/ delta TCR-bearing T cells in vitro, and to deplete peripheral gamma/ delta TCR-bearing T cells in vivo.
General Readings
  1. Skarstein, K., et al., 1995. Immunology 81: 497. 2. Harrison, L.C., et al., 1996. J. Exp. Med. 184:2167. 3. Wildner, G., et al., 1996. Eur. J. Immunol. 26: 2140.
Storage Store at 4C. Do not freeze.
Immunogen affinity purified
Buffer System:
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Immunogen affinity purified

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