AM26003PP-N T Cell Receptor (TCR) alpha/beta antibody

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100 Tests / €290.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Human T Cell Receptor (TCR) alpha/beta IP26

AM26003PP-N

Product Description for T Cell Receptor (TCR) alpha/beta

Mouse anti Human T Cell Receptor (TCR) alpha/beta IP26.
Presentation: PerCP
Product is tested for Flow Cytometry.

Properties for T Cell Receptor (TCR) alpha/beta

Product Category Primary Antibodies
Quantity 100 Tests
Presentation PerCP
Reactivity Hu
Applications F
Clonality Monoclonal
Clone IP26
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Application Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension.
The content of a vial (1 ml) is sufficient for 100 tests.
Background The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.
General Readings
  1. von Boehmer H: T cell development and selection in the thymus. Bone Marrow Transplant. 1992;9 Suppl 1:46-8. 2. Levelt CN, Wang B, Ehrfeld A, Terhorst C, Eichmann K: Regulation of T cell receptor (TCR)-beta locus allelic exclusion and initiation of TCR-alpha locus rearrangement in immature thymocytes by signaling through the CD3 complex. Eur J Immunol. 1995 May;25(5):1257-61. 3. Michie AM, Zúñiga-Pflücker JC: Regulation of thymocyte differentiation: pre-TCR signals and beta-selection. Semin Immunol. 2002 Oct;14(5):311-23. 4. Croxford AL, Akilli-Ozturk O, Rieux-Laucat F, Förster I, Waisman A, Buch T: MHC-restricted T cell receptor signaling is required for alpha beta TCR replacement of the pre T cell receptor. Eur J Immunol. 2008 Feb;38(2):391-9. 5. Huet D, Bagot M, Loyaux D, Capdevielle J, Conraux L, Ferrara P, Bensussan A, Marie-Cardine A: SC5 mAb represents a unique tool for the detection of extracellular vimentin as a specific marker of Sezary cells. J Immunol. 2006 Jan 1;176(1):652-9. 6. Ortonne N, Huet D, Gaudez C, Marie-Cardine A, Schiavon V, Bagot M, Musette P, Bensussan A: Significance of circulating T-cell clones in Sezary syndrome. Blood. 2006 May 15;107(10):4030-8. 7. Chentouf M, Ghannam S, Bès C, Troadec S, Cérutti M, Chardès T: Recombinant anti-CD4 antibody 13B8.2 blocks membrane-proximal events by excluding the Zap70 molecule and downstream targets SLP-76, PLC gamma 1, and Vav-1 from the CD4-segregated Brij 98 detergent-resistant raft domains. J Immunol. 2007 Jul 1;179(1):409-20. Sullivan BM, Coscoy L: Downregulation of the T-cell receptor complex and impairment of T-cell activation by human herpesvirus 6 u24 protein. J Virol. 2008 Jan;82(2):602-8. 8. Kuttruff S, Koch S, Kelp A, Pawelec G, Rammensee HG, Steinle A: NKp80 defines and stimulates a reactive subset of CD8 T cells. Blood. 2009 Jan 8;113(2):358-69.
Storage Store undiluted at 2-8°C. DO NOT FREEZE!
This products is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Format
Label:
Conjugated with Peridinin-chlorophyll-protein complex (PerCP) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
PerCP
Buffer System:
Phosphate buffered saline (PBS)
Preservatives:
15 mM sodium azide
Stabilizers:
0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA)
State:
Liquid purified Ig fraction
Species Reactivity
Species reactivity (tested):
Human
Specificity
Specificity:
This antibody recognizes a monomorphic determinant of TCR alpha/beta, the dominant subtype of T cell receptor expressed in human peripheral blood.

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