AM05098PU-N T Cell Receptor (TCR) V beta 13.1 antibody

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Mouse anti Human T Cell Receptor (TCR) V beta 13.1 Immu222


Product Description for T Cell Receptor (TCR) V beta 13.1

Mouse anti Human T Cell Receptor (TCR) V beta 13.1 Immu222.
Presentation: Purified
Product is tested for Flow Cytometry.

Properties for T Cell Receptor (TCR) V beta 13.1

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms TCR V beta-13.1, TCR Vb13.1
Presentation Purified
Reactivity Hu
Applications F
Clonality Monoclonal
Clone Immu222
Host Mouse
Isotype IgG2b
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Murine T cell hybridoma transfected with human V beta-13.1 gene segment
Isotype control AM03110PU-N, SM12P
Application T-cell repertoire studies.
Fluorescent microscopy or flow cytometry: 2µg / 5 x 10e5 cells/tests or 100µl whole blood.
General Readings
  1. Wei S, Charmley P, Robinson MA, Concannon P. The extent of the human germline T-cell receptor V beta gene segment repertoire. Immunogenetics. 1994;40(1):27-36. PubMed PMID: 8206523.
  2. Li, Y., et al., (1991), :The genomic structure of human V Beta 6 TCR genes, J. Exp. Med., 174, 1537 - 1547.
  3. Kimura N, Toyonaga B, Yoshikai Y, Triebel F, Debre P, Minden MD, et al. Sequences and diversity of human T cell receptor beta chain variable region genes. J Exp Med. 1986 Sep 1;164(3):739-50. PubMed PMID: 3755748. (Free PMC Article available)
  4. Ferradini, L., et al., Studies on the human TCR alpha beta variable region genesll. Identification of four additional V beta subfamilies, Eur. J. Immunol., 21, 935 - 942.
  5. Posnett, D.N., et al., (1996), First human TcR monoclonal antibody workshop, The Immunologist, 4, 1, 5 - 8.
Storage Prior to reconstitution store at 2-8°C.
Following reconstitution store the antibody at -20°C.
The addition of 0.1% (w/v) sodium azide is recommended for storage of the reconstituted form for up to 1 month at 2 - 8°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Buffer System:
PBS containing 1mg/ml BSA
Lyophilized purified Ig
Restore with 0.5ml of distilled water
This antibody reacts to the variable beta-13.1 chain of the T cell receptor also called TCRBV13S1 according to the nomenclature from Wei et al. V beta-13.1 is a complex subfamily of the TCR. This antibody recognizes the V beta-13.1 member (HBP34 sequence). The sequence V beta-13.3 (IGRb14) is not recognized. The antibody was characterized on human T-cell clones and by cell sorting followed by molecular analysis of the sorted cells. All of 11 sequence analyzed were V beta-13.1 subfamily cannot be formally excluded. It was been recently shown that Immu222 could recognize V beta-13.4 (Clone 4.1 sequence) and V beta-13.6 (IGRb16 sequence) subsets. No crossreactivity was detected with any of 18 V beta specific antibodies (representing - 70% of the alpha/beta repertoire) on a cell line sorted from PBL and 100% positive with Immu222.

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