AM05096FC-N T Cell Receptor (TCR) Va 24 antibody

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Mouse anti Human T Cell Receptor (TCR) Va 24 C15


Product Description for T Cell Receptor (TCR) Va 24

Mouse anti Human T Cell Receptor (TCR) Va 24 C15.
Presentation: FITC
Product is tested for Immunocytochemistry/Immunofluorescence, Flow Cytometry.

Properties for T Cell Receptor (TCR) Va 24

Product Category Primary Antibodies
Quantity 50 Tests
Synonyms TCR V alpha-24, TCR Va24
Presentation FITC
Reactivity Hu
Applications F, ICC/IF
Clonality Monoclonal
Clone C15
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Human T-cell clone.
Mouse. Hybridization of PAI myeloma cells with spleen cells from Balb/c mice.
Isotype control SM10F (for use in human samples)
Application T-cell repertoire research studies.
Background A population of mature CD4 CD8 double-negative T cells that expresses an invariant V alpha 24-J alpha Q TCR has been identified in humans; the majority of these cells appear to express V beta 11. A closely related invariant TCR alpha chain is also expressed by a population of NK1+ murine T cells, but these cells may be either CD4+ or double negative.
Concentration 25 µg/ml
General Readings
  1. Arden, B., et al., (1995), Human T cell receptor variable gene segment families, Immunogenetics, 42, 455-500.
  2. Roman-Roman, S., et al., (1991), Studies on the human T-cell receptor alpha/beta variable region genes I. Identification of 7 addition V-alpha subfamilies and 14 J-alpha gene segments, Eur. J. Immunol., 21, 927-933.
  3. Padovan, E., et al., (1993), Expression of two T-cell receptor alpha chains: Dual receptor T cells, Science, 262, 422-424.
  4. Dellabona P, Padovan E, Casorati G, Brockhaus M, Lanzavecchia A. An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells. J Exp Med. 1994 Sep 1;180(3):1171-6. PubMed PMID: 8064234. (Free PMC Article available)
  5. Posnett, D.N., et al., (1996), First Human TcR Monoclonal Antibody Workshop, The Immunologist, 4, (1), 5-8.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Ion Exchange Chromatography.
Buffer System:
PBS containing 2 mg/ml BSA as stabilizer and 0.09% Sodium Azide as preserative.
Liquid purified Ig fraction.
Human variable alpha-24 chain of the T cell receptor also called TCRAV24S1 according to the nomenclature from Arden et al.(1). V-alpha-24 is a single membered subfamily (IGRa02 sequence (2)). The antibody has been described in (3,4); it was characterized on human T cell clones and by extensive cell sorting followed by molecular biology analysis. V-alpha-24 has been shown to be expanded in a clonal fashion in the CD3+ CD8- CD4- cell population in PBL of several donors.(3,4).
The specificity of this antibody has been confirmed at the First Human TcR Monoclonal Antibody Workshop in San Francisco in 1995 (Ref.5).

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