AM05096FC-N T Cell Receptor (TCR) Va 24 antibody

See related secondary antibodies

Search for all "T Cell Receptor (TCR) Va 24"

50 Tests / €610.00

Quick Overview

Mouse anti Human T Cell Receptor (TCR) Va 24 C15


Product Description for T Cell Receptor (TCR) Va 24

Mouse anti Human T Cell Receptor (TCR) Va 24 C15.
Presentation: FITC
Product is tested for Immunocytochemistry/Immunofluorescence, Flow Cytometry.

Properties for T Cell Receptor (TCR) Va 24

Product Category Primary Antibodies
Quantity 50 Tests
Synonyms TCR V alpha-24, TCR Va24
Presentation FITC
Reactivity Hu
Applications F, ICC/IF
Clonality Monoclonal
Clone C15
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Human T-cell clone.
Mouse. Hybridization of PAI myeloma cells with spleen cells from Balb/c mice.
Isotype control SM10F (for use in human samples)
Application T-cell repertoire research studies.
Background A population of mature CD4 CD8 double-negative T cells that expresses an invariant V alpha 24-J alpha Q TCR has been identified in humans; the majority of these cells appear to express V beta 11. A closely related invariant TCR alpha chain is also expressed by a population of NK1+ murine T cells, but these cells may be either CD4+ or double negative.
Concentration 25 µg/ml
General Readings
  1. Arden, B., et al., (1995), Human T cell receptor variable gene segment families, Immunogenetics, 42, 455-500.
  2. Roman-Roman, S., et al., (1991), Studies on the human T-cell receptor alpha/beta variable region genes I. Identification of 7 addition V-alpha subfamilies and 14 J-alpha gene segments, Eur. J. Immunol., 21, 927-933.
  3. Padovan, E., et al., (1993), Expression of two T-cell receptor alpha chains: Dual receptor T cells, Science, 262, 422-424.
  4. Dellabona P, Padovan E, Casorati G, Brockhaus M, Lanzavecchia A. An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells. J Exp Med. 1994 Sep 1;180(3):1171-6. PubMed PMID: 8064234. (Free PMC Article available)
  5. Posnett, D.N., et al., (1996), First Human TcR Monoclonal Antibody Workshop, The Immunologist, 4, (1), 5-8.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Ion Exchange Chromatography.
Buffer System:
PBS containing 2 mg/ml BSA as stabilizer and 0.09% Sodium Azide as preserative.
Liquid purified Ig fraction.
Human variable alpha-24 chain of the T cell receptor also called TCRAV24S1 according to the nomenclature from Arden et al.(1). V-alpha-24 is a single membered subfamily (IGRa02 sequence (2)). The antibody has been described in (3,4); it was characterized on human T cell clones and by extensive cell sorting followed by molecular biology analysis. V-alpha-24 has been shown to be expanded in a clonal fashion in the CD3+ CD8- CD4- cell population in PBL of several donors.(3,4).
The specificity of this antibody has been confirmed at the First Human TcR Monoclonal Antibody Workshop in San Francisco in 1995 (Ref.5).

Accessory Products

  • LinkedIn