AM05096PU-N T Cell Receptor (TCR) Va 24 antibody

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Mouse anti Human T Cell Receptor (TCR) Va 24 C15


Product Description for T Cell Receptor (TCR) Va 24

Mouse anti Human T Cell Receptor (TCR) Va 24 C15.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Flow Cytometry.

Properties for T Cell Receptor (TCR) Va 24

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms TCR V alpha-24, TCR Va24
Presentation Purified
Reactivity Hu
Applications F, ICC/IF
Clonality Monoclonal
Clone C15
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Human T-Cell clone
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application T-cell repertoire studies.
Fluorescent microscopy or flow cytometry: 2µg/5x10e5 cells/tests.
Background A population of mature CD4 CD8 double-negative T cells that expresses an invariant V alpha 24-J alpha Q TCR has been identified in humans; the majority of these cells appear to express V beta 11. A closely related invariant TCR alpha chain is also expressed by a population of NK1+ murine T cells, but these cells may be either CD4+ or double negative.
General Readings
  1. Arden, B., et al., (1995), Human T cell receptor variable gene segment families, Immunogenetics, 42, 455 - 500.
  2. Roman-Roman, S., et al., (1991), Studies of the human T-cell receptor alpha/beta variable region genes I. Identification of 7 additional V-alpha subfamilies and 14 J-alpha gene segments, Eur. J. Immunol., 21, 927 - 933.
  3. Padovan, E., et al., (1993), Expression of two T-cell receptor alpha chains: Dual receptor T cells, Science, 262, 422 - 424.
  4. Dellabona, P., et al., (1994), An invariant V-alpha-24-J-Alpha Q/V-beta-11 T-cell receptor is expressed in all individuals by clonally expanded CD4-8-T cells, J. Exp. Med., 180, 1171 - 1176.
  5. Posnett, D.N., et al., (1996), First human TcR monoclonal antibody workshop, The Immunologist, 4, 1, 5 - 8.
Storage Prior to reconstitution store at 2-8°C.
Following reconstitution store the antibody at -20°C.
The addition of 0.1% (w/v) sodium azide is recommended for storage of the reconstituted form for up to one month at 2 - 8°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Ion exchange chromatography
Buffer System:
PBS containing 1mg/ml BSA
Lyophilized purified Ig
Restore with 0.5ml of distilled water
This antibody reacts to the variable alpha-24 chain of the T cell receptor also called TCRAV24S1 according to the nomenclature from Arden et al. V-alpha-24 is a single membered subfamily (IGRa02 sequence). The antibody has been described in; it was characterized on human T cell clones and by extensive cell sorting followed by molecular biology analysis. V-alpha-24 has been shown to be expanded in a clonal fashion in the CD3+ CD8- CD4-cell population in PBL of several donors. The specificity of this antibody has been studied at the First Human TcR Monoclonal Antibody Workshop in San Francisco in 1995.

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