discontinued

AM05096PU-N T Cell Receptor (TCR) Va 24 antibody

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0.1 mg / €530.00

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Mouse anti Human T Cell Receptor (TCR) Va 24 C15

AM05096PU-N

Product Description for T Cell Receptor (TCR) Va 24

Mouse anti Human T Cell Receptor (TCR) Va 24 C15.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Flow Cytometry.

Properties for T Cell Receptor (TCR) Va 24

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms TCR V alpha-24, TCR Va24
Presentation Purified
Reactivity Hu
Applications F, ICC/IF
Clonality Monoclonal
Clone C15
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Human T-Cell clone
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application T-cell repertoire studies.
Fluorescent microscopy or flow cytometry: 2µg/5x10e5 cells/tests.
Background A population of mature CD4 CD8 double-negative T cells that expresses an invariant V alpha 24-J alpha Q TCR has been identified in humans; the majority of these cells appear to express V beta 11. A closely related invariant TCR alpha chain is also expressed by a population of NK1+ murine T cells, but these cells may be either CD4+ or double negative.
General Readings
  1. Arden, B., et al., (1995), Human T cell receptor variable gene segment families, Immunogenetics, 42, 455 - 500.
  2. Roman-Roman, S., et al., (1991), Studies of the human T-cell receptor alpha/beta variable region genes I. Identification of 7 additional V-alpha subfamilies and 14 J-alpha gene segments, Eur. J. Immunol., 21, 927 - 933.
  3. Padovan, E., et al., (1993), Expression of two T-cell receptor alpha chains: Dual receptor T cells, Science, 262, 422 - 424.
  4. Dellabona, P., et al., (1994), An invariant V-alpha-24-J-Alpha Q/V-beta-11 T-cell receptor is expressed in all individuals by clonally expanded CD4-8-T cells, J. Exp. Med., 180, 1171 - 1176.
  5. Posnett, D.N., et al., (1996), First human TcR monoclonal antibody workshop, The Immunologist, 4, 1, 5 - 8.
Storage Prior to reconstitution store at 2-8°C.
Following reconstitution store the antibody at -20°C.
The addition of 0.1% (w/v) sodium azide is recommended for storage of the reconstituted form for up to one month at 2 - 8°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Ion exchange chromatography
Buffer System:
PBS containing 1mg/ml BSA
State:
Lyophilized purified Ig
Purified
Reconstitution:
Restore with 0.5ml of distilled water
Specificity
Specificity:
This antibody reacts to the variable alpha-24 chain of the T cell receptor also called TCRAV24S1 according to the nomenclature from Arden et al. V-alpha-24 is a single membered subfamily (IGRa02 sequence). The antibody has been described in; it was characterized on human T cell clones and by extensive cell sorting followed by molecular biology analysis. V-alpha-24 has been shown to be expanded in a clonal fashion in the CD3+ CD8- CD4-cell population in PBL of several donors. The specificity of this antibody has been studied at the First Human TcR Monoclonal Antibody Workshop in San Francisco in 1995.
Species:
Human.

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