NB100-64285 T Cell Receptor (TCR) Vb 7 antibody

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Rat anti Mouse T Cell Receptor (TCR) Vb 7 TR310


Product Description for T Cell Receptor (TCR) Vb 7

Rat anti Mouse T Cell Receptor (TCR) Vb 7 TR310.
Presentation: Purified
Product is tested for Flow Cytometry.

Properties for T Cell Receptor (TCR) Vb 7

Product Category Primary Antibodies
Quantity 0.2 mg
Synonyms TCR V beta-7, TCR Vb7
Presentation Purified
Reactivity Ms
Applications F
Clonality Monoclonal
Clone TR310
Host Rat
Isotype IgG2b
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

T-cell lymphoma TK1
Application flow cytometry / FACS analysis
Background The receptors on T cells consist of immunoglobulin like integral membrane glycoproteins containing 2 polypeptide subunits, alpha and beta, of similar molecular weight, 40 to 55 kD in the human. Like the immunoglobulins of the B cells, each T cell receptor subunit has, external to the cell membrane, an N terminal variable domain and a C terminal constant domain.
T cell receptors recognise foreign antigens which have been processed as small peptides and bound to major histocompatibility complex molecules at the surface of antigen presenting cells. Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci.
Concentration 0.2 mg/ml
General Readings Reading
1. Okada, C.Y. et al. (1990) Characterization of a rat monoclonal antibody specific for a determinant encoded by the Vb7 gene segment - deletion of Vb7+ T cells in mice with MIS-1a haplotype. J. Immunol. 144: 3473-3477.
2. Suhihara, S. et al. (1993) Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. J. Immunol. 150: 683-694.
3. Ignatowicz, L. et al. (1994) Identification of two Vb7-specific viral superantigens. J. Immunol. 152: 65-71.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
protein A purified
Buffer System:
Phosphate buffered saline
protein A purified
Mouse. Not yet tested in other species.

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