Product Description for t-PA / PLAT
Sheep anti Rabbit t-PA / PLAT.
Presentation: Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.
Presentation: Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.
Properties for t-PA / PLAT
| Product Category | Primary Antibodies |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | Alteplase, Reteplase, Tissue-type plasminogen activator, tPA |
| Presentation | Purified |
| Reactivity | Rb |
| Applications | E, WB |
| Clonality | Polyclonal |
| Host | Sheep |
| Shipping to | Not USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | Novus Biologicals Inc. |
Datasheet Extract
| Immunogen |
|
|---|---|
| Application | ELISA, Western Blot, ELISA and Western Blot, ELISA 1:100000, Western Blot 1-5 ug/ml |
| Background | TPA converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. TPA binds to fibrin with high affinity; this leads to an increase in the catalytic efficiency of the enzyme of 100- to 1000-fold, due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binding to laminin and fibronectin has also been demonstrated. TPA also binds to mannose receptor and the low density lipoprotein receptor related protein (LRP1). These proteins are involved in TPA clearance. TPA binds to annexin II and to cytokeratin 8. As yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation. Binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold. |
| Concentration | 1 mg/ml |
| Storage | Store at -80C. Avoid freeze-thaw cycles. |
| Format |
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| Specificity |
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Accessory Products
Recommended Secondary Antibodies for t-PA / PLAT (6 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1433R |
Sheep IgG (H+L chain), adsorbed F(ab')2 Fragment antibody |
||||||
|
Donkey | PE | |||||
| Acris Antibodies GmbH | |||||||
| R1456AP |
Sheep IgG (H+L chain) antibody |
||||||
|
|
Rabbit | AP | |||||
| Acris Antibodies GmbH | |||||||
| R1456B |
Sheep IgG (H+L chain) antibody |
||||||
|
|
Rabbit | Biotin | |||||
| Acris Antibodies GmbH | |||||||
| R1456F |
Sheep IgG (H+L chain) antibody |
||||||
|
|
Rabbit | FITC | |||||
| Acris Antibodies GmbH | |||||||
| R1456HRP |
Sheep IgG (H+L chain) antibody |
||||||
|
|
Rabbit | HRP | |||||
| Acris Antibodies GmbH | |||||||
| R1456T |
Sheep IgG (H+L chain) antibody |
||||||
|
|
Rabbit | TRITC | |||||
| Acris Antibodies GmbH | |||||||
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