TA347306 TET2 antibody

Mouse Monoclonal TET2 Antibody

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50 µg / €325.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Human, Mouse TET2 Monoclol

TA347306

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  • TA347306

Product Description for TET2

Mouse anti Human, Mouse TET2 Monoclol.
Presentation: Purified

Properties for TET2

Product Category Primary Antibodies
Target Category
Quantity 50 µg
Synonyms KIAA1546, Methylcytosine dioxygenase TET2
Presentation Purified
Reactivity Hu, Ms
Clonality Monoclonal
Clone Monoclol
Host Mouse
Isotype IgG1
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q6N021
Immunogen:
The immunogen for anti-TET2 antibody: the a recombinant protein containing the N-terminal 300 amino acids of human TET2 (tet oncogene family member 2).
GeneID:
54790
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application Western blotting (1:1
000-1:1
200); IP (5ug per mg of RIPA lysate)
Background TET2 (UniProt/Swiss-Prot entry Q6N021) is a methylcytosine dioxygese that catalyzes the conversion of 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC). 5-hmC has been recently discovered in mammalian D and is abundant in Purkinje neurons, granule cells, embryonic stem cells, and brain tissue, especially in areas that are associated with higher cognitive function. Although its precise role has still to be shown, recent studies indicate that 5-hmC plays important roles distinct from 5-mC. Early evidence suggests that 5-hmC may represent a new pathway to demethylate D involving a repair mechanism converting 5-hmC to cytosine. Mutations in TET2 have been associated with myeloproliferative diseases such as essential thrombocythemia, polycythemia vera and primary myelofibrosis.
Format
Purification:
Protein G purified polyclol antibody in PBS containing 0.05% azide.
State:
Purified

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