NBP1-01035 TFNR / BDP1 antibody

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Rabbit anti Human, Mouse TFNR / BDP1


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  • NBP1-01035

Product Description for TFNR / BDP1

Rabbit anti Human, Mouse TFNR / BDP1.
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Paraffin Sections, Western blot / Immunoblot.

Properties for TFNR / BDP1

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms KIAA1241, KIAA1689, TFIIIB150, Transcription factor IIIB 150, Transcription factor TFIIIB component B\'\' homolog, Transcription factor-like nuclear regulator
Presentation Aff - Purified
Reactivity Hu, Ms
Applications ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Application ELISA, immunohistochemistry, Western Blot, Western blot analysis of TFIIIB90-1 (E257) antibody in extracts from HeLa cells ., ELISA 1:1000-1:5000, Western Blot 1:500-1:1000, immunohistochemistry 1:50-1:200,
Background RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (TFIIIB90, BRF1) and TFIIIB, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.
Concentration 1 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Immunogen affinity purified
Buffer System:
15mM Sodium Azide
Immunogen affinity purified
Aff - Purified
TFIIIB90-1 (E257) detects endogenous levels of TFIIIB90-1 protein.
Human, Mouse

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