GTX10853 TGFBR2 antibody

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50 µg / €390.00

Quick Overview

Goat anti Human TGFBR2


Product Description for TGFBR2

Goat anti Human TGFBR2.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Neutralisation, Western blot / Immunoblot, Paraffin Sections.

Properties for TGFBR2

Product Category Primary Antibodies
Quantity 50 µg
Presentation Aff - Purified
Reactivity Hu
Applications E, NEUT, P, WB
Clonality Polyclonal
Host Goat
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Recombinant human soluble TGFBR2, expressed in NSO cells.
Application ELISA, IHC-P, Neut, WB
Background Most mammalian cells express three abundant high affinity receptors, which can bind and be cross-linked to TGF beta: the type I (53 kDa), type II (65 kDa), and type III (100-280 kDa) receptors, based upon the molecular mass of the cross-linked products analyzed by gel electrophoresis. Tbeta-RI and Tbeta-RII, the type I and II receptors, are type I transmembrane proteins with cytosolic domains containing a serine-threonine kinase. Both receptors are essential for signal transduction. The TGF-beta type III receptor, or betaglycan, is a membrane-bound proteoglycan with a short cytoplasmic tail that has no apparent signaling motif. It binds TGF beta 2 (apparent Kd 100 pM) with slightly greater affinity than TGF beta 1 or TGF beta 3 (apparent Kda 300 pM). The main role of beta glycan seems to be in binding and then presenting TGF beta ligand to the signaling receptors Tbeta-RI and Tbeta- RII; overexpression of Tbeta-RIII in L6 myoblasts leads to a dramatic increase in TGF beta 2 binding to Tbeta-RI and Tbeta-RII.
Concentration 1 mg/ml
Storage Keep as concentrated solution. Store at 4
Immunogen affinity purified
Buffer System:
Preservative: NoneConstituents: PBS
Immunogen affinity purified
Aff - Purified
Human - Not yet tested in other species

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