discontinued

GTX10853 TGFBR2 antibody

See related secondary antibodies

Search for all "TGFBR2"

50 µg / €390.00

Quick Overview

Goat anti Human TGFBR2

GTX10853

Product Description for TGFBR2

Goat anti Human TGFBR2.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Neutralisation, Western blot / Immunoblot, Paraffin Sections.

Properties for TGFBR2

Product Category Primary Antibodies
Quantity 50 µg
Presentation Aff - Purified
Reactivity Hu
Applications E, NEUT, P, WB
Clonality Polyclonal
Host Goat
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Recombinant human soluble TGFBR2, expressed in NSO cells.
Application ELISA, IHC-P, Neut, WB
Background Most mammalian cells express three abundant high affinity receptors, which can bind and be cross-linked to TGF beta: the type I (53 kDa), type II (65 kDa), and type III (100-280 kDa) receptors, based upon the molecular mass of the cross-linked products analyzed by gel electrophoresis. Tbeta-RI and Tbeta-RII, the type I and II receptors, are type I transmembrane proteins with cytosolic domains containing a serine-threonine kinase. Both receptors are essential for signal transduction. The TGF-beta type III receptor, or betaglycan, is a membrane-bound proteoglycan with a short cytoplasmic tail that has no apparent signaling motif. It binds TGF beta 2 (apparent Kd 100 pM) with slightly greater affinity than TGF beta 1 or TGF beta 3 (apparent Kda 300 pM). The main role of beta glycan seems to be in binding and then presenting TGF beta ligand to the signaling receptors Tbeta-RI and Tbeta- RII; overexpression of Tbeta-RIII in L6 myoblasts leads to a dramatic increase in TGF beta 2 binding to Tbeta-RI and Tbeta-RII.
Concentration 1 mg/ml
Storage Keep as concentrated solution. Store at 4
Format
Purification:
Immunogen affinity purified
Buffer System:
Preservative: NoneConstituents: PBS
Purity:
Immunogen affinity purified
State:
Liquid
Aff - Purified
Specificity
Specificity:
Human - Not yet tested in other species

Accessory Products

  • LinkedIn