discontinued

NBP1-05082 Thioguanine (2-amino-6-mercaptopurine) antibody

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0.1 mg / €340.00

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Mouse anti Thioguanine (2-amino-6-mercaptopurine)

NBP1-05082

Product Description for Thioguanine (2-amino-6-mercaptopurine)

Mouse anti Thioguanine (2-amino-6-mercaptopurine).
Presentation: Purified
Product is tested for Enzyme Immunoassay.

Properties for Thioguanine (2-amino-6-mercaptopurine)

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Applications E
Clonality Polyclonal
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
7-substituted thioguanine linked to PPD (2)
Background Thioguanine is a purine analogue used in cancer chemotherapy. It is the 6-thione analogue of the endogenous 6-OH purine base guanine. In the cell thioguanine is converted to the ribonucleotides: 6-thioguanosine-5'-phosphate and 6-thioinosine-5'-phosphate. These fraudulent nucleotides produce their cytotoxic effects by several mechanisms, e.g. inhibitory action on de novo purine synthesis, and may themselves be incorporated into DNA. Thioguanine has a molecular weight of 167 Da (1,2).
Concentration 1 mg/ml
General Readings
  1. Rang HP, Dale MM, Ritter JM (1995) Chemotherapy. Pharmacology. New York: Churchill Livingstone 696-717.
  2. Nerstrøm VM, Henriksen U, Nielsen PE, Buchardt O, Schmiegelow K, Koch C. Monoclonal antibodies to thioguanine: influence of coupling position on fine specificity. Bioconjug Chem. 1994 Jul-Aug;5(4):357-63. PubMed PMID: 7948103.
Storage Store at 4C. Do not freeze.
Format
Purification:
protein A purified
Buffer System:
15mM Sodium Azide
Purity:
protein A purified
State:
Purified
Specificity
Specificity:
This has specificity for thioguanine. Cross reactivity is seen with a variety of thioguanine analogues except 6-thioxanthine and 2-amino-6-(methylthio)purine (2).

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