DM3211 Thrombospondin antibody

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Mouse anti Bovine, Chicken, Human, Mouse, Rat Thrombospondin A4.1


Product Description for Thrombospondin

Mouse anti Bovine, Chicken, Human, Mouse, Rat Thrombospondin A4.1.
Presentation: Purified
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for Thrombospondin

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Bov, Chk, Hu, Ms, Rt
Applications C, ICC/IF, WB
Clonality Monoclonal
Clone A4.1
Host Mouse
Isotype IgM
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Biomeda

Datasheet Extract

Calcium-replete, native purified human TSP from the supernatant of thrombin-activaed platelets.
Isotype control SM13P
Application Blocks Binding of TSP-1 to TSP-Rec. / CD361 (Order Ab without azide). Flow Cytometry. Immunofluorescence. Western Blotting (Ab 1-2µg/ml for 2hrs at RT)(Nonreduced only). Recommended positive control: HUVEC Cells. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
Concentration 0.2 mg/ml
Storage Store the antibody at 4°C. Do not freeze! Shelf life: one year from despatch.
Thrombospondin is a protein from platelet alpha-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells. This antibody blocks anti-angiogenic activity of TSP-1 by inhibiting its binding to TSP-Receptor / CD36. It shows no cross-reaction with fibronectin, fibrinogen, and von Willebrand factor. It inhibits the adhesion of human melanoma G361 cells, keratinocytes, squamous carcinoma cells, and rat smooth muscle cells. It does not inhibit aggregation of thrombin-induced platelets. Reacts with Human, Mouse, Rat, Cow, and Chicken. Others not tested. Cellular Localization: Secretory Granules, Golgi Complex, Endoplasmic Reticulum, Extracellular Matrix.

Mol. Wt of Antigen: ~450kD (non-reduced)

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