NB100-75141 Thymidylate synthase antibody

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Chicken anti Bacteria Thymidylate synthase


Product Description for Thymidylate synthase

Chicken anti Bacteria Thymidylate synthase.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for Thymidylate synthase

Product Category Primary Antibodies
Quantity 1 mg
Presentation Aff - Purified
Reactivity Bac
Applications WB
Clonality Polyclonal
Host Chicken
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Swiss Prot Num:
The immunogen for this antibody was a sequence from 1a.a. to 264a.a. from Thymidylate synthase(a 264a.a. long protein)
Application Western Blot
Background Thymidylate synthase (TS) is an intracellular enzyme critical for de novo synthesis of DNA. In cancer, expression of TS is often elevated and becomes further elevated as a result of treatment with the most commonly used chemotherapeutic, 5-fluorouracil (5-FU). Resistance or lack of response to 5-FU is attributed to the elevation of TS activity. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma and is usually predictive of shortened survival time.

Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation (By similarity). Catalytic Activity: 5.10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.Pathway: Nucleotide biosynthesis; deoxyribonucleotide biosynthesis.Subunit: Homodimer (By similarity).Subcellular Location: Cytoplasm (By similarity).Ptm: The N-terminus is carboxylated (By similarity).Similarity: Belongs to the thymidylate synthase family.
General Readings
  1. Welch,R.A., Burland,V., Plunkett,G.D. III, Redford,P., Roesch,P., Rasko,D.A., Buckles,E.L., Liou,S.-R., Boutin,A., Hackett,J.,, et al. Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli.
  2. , Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., et al. Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Affinity purified
Buffer System:
Phosphate-Buffered Saline.
Affinity purified
Aff - Purified
This antibody is reactive against E coli.
Gene ID 1039295

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