discontinued

GTX23145 Thymidylate Synthase [TS 106] antibody

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0.5 ml / €380.00

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Mouse anti Human Thymidylate Synthase [TS 106] TS 106

GTX23145

Product Description for Thymidylate Synthase [TS 106]

Mouse anti Human Thymidylate Synthase [TS 106] TS 106.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot, Flow Cytometry, Paraffin Sections.

Properties for Thymidylate Synthase [TS 106]

Product Category Primary Antibodies
Quantity 0.5 ml
Presentation Purified
Reactivity Hu
Applications F, ICC/IF, IP, P, WB
Clonality Monoclonal
Clone TS 106
Host Mouse
Isotype IgG1
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Recombinant full length protein (Human).
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application FACS, IF, IHC-P, IP, WB
Background Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10 methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Concentration 0.2 mg/ml
Storage Keep as concentrated solution, aliquot and store at 4
Format
Purification:
Protein G purified
Buffer System:
10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Purity:
Protein G purified
State:
Liquid
Purified
Specificity
Specificity:
Human - Not yet tested in other species

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