Product Description for TLR (Intracellular) 4x Sampler Kit
Product is tested for Immunoprecipitation, Paraffin Sections, Western blot / Immunoblot, Flow Cytometry.
Properties for TLR (Intracellular) 4x Sampler Kit
|Product Category||Primary Antibodies|
|Quantity||4 x 25 µg|
|Reactivity||Hu, Ms, Rt|
|Applications||F, IP, P, WB|
|PDF datasheet||View Datasheet|
|Manufacturer||Acris Antibodies GmbH|
|Material safety datasheet||MSDS for Polyclonal Antibodies (de)|
|Add. information||TLR (Intracellular) Screening Set contains 4 Polyclonal or Monoclonal Antibodies:
Cat.-No SM7101P-25: TLR3 Antibody
Cat.-No SP7198P-25: TLR7 Antibody
Cat.-No SM7104P-25: TLR8 Antibody
Cat.-No SM7105P-25: TLR9 Antibody
|Application||Western blot analysis.
Confocal Microscopy .
Immunohistochemistry on Paraffin Sections.
|Background||The Toll-like receptor (TLR) family in mammals comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLR3, 7, 8, and 9 are expressed in the intracellular organelles. TLR7 and TLR8 have a common ligand, viral single-stranded RNA. TLR3 is activated by viral double-stranded RNA. TLR9 responds to bacterial unmethylated CpG DNA. Ten human homologs of TLRs (TLR1-10) have been described.|