AM26199BT-N TLR2 antibody

See related secondary antibodies

Search for all "TLR2"

50 µg / €280.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human TLR2 TLR2.45

AM26199BT-N

Product Description for TLR2

Mouse anti Human TLR2 TLR2.45.
Presentation: Biotin
Product is tested for Immunocytochemistry/Immunofluorescence.

Properties for TLR2

Product Category Primary Antibodies
Quantity 50 µg
Presentation Biotin
Reactivity Hu
Applications ICC/IF
Clonality Monoclonal
Clone TLR2.45
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Ba/F3 cells which stably express human Flag-tagged TLR2
Isotype control SM10B (for use in human samples)
Application Flow cytometry: Typical starting working dilution is 1:50.
Immunoflourescence: Typical starting working dilution is 1:50.
Background

Toll-like receptors (TLR) are highly conserved throughout evolution and are implicated in the innate defense to many pathogens. Mammalian TLRs have been identified as type I transmembrane signaling receptors with pattern recognition capabilities. TLRs recognize pathogen-associated molecular patterns (PAMPs), expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression.
Among TLRs, TLR2 is an unique receptor recognizing lipoproteins of Gram-negative bacteria, several whole Gram-positive bacteria, as well as peptidoglycan, lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2 (CD282).
TLR2 is highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Furthermore, TLR2 is detected in lung and fetal liver. In other tissues TLR2 levels are low.

Concentration 0.1 mg/ml
General Readings
  1. Nakao Y, Funami K, Kikkawa S, Taniguchi M, Nishiguchi M, Fukumori Y, et al. Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells. J Immunol. 2005 Feb 1;174(3):1566-73. PubMed PMID: 15661917.
  2. Uehori J, Fukase K, Akazawa T, Uematsu S, Akira S, Funami K, et al. Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation. J Immunol. 2005 Jun 1;174(11):7096-103. PubMed PMID: 15905553.
  3. Funami K, Matsumoto M, Oshiumi H, Akazawa T, Yamamoto A, Seya T. The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling. Int Immunol. 2004 Aug;16(8):1143-54. Epub 2004 Jun 28. PubMed PMID: 15226270.
  4. Matsumoto M, Funami K, Tanabe M, Oshiumi H, Shingai M, Seto Y, et al. Subcellular localization of Toll-like receptor 3 in human dendritic cells. J Immunol. 2003 Sep 15;171(6):3154-62. PubMed PMID: 12960343.
  5. Uehori J, Matsumoto M, Tsuji S, Akazawa T, Takeuchi O, Akira S, et al. Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan. Infect Immun. 2003 Aug;71(8):4238-49. PubMed PMID: 12874299. (Free PMC Article available, 6 images available)
Storage

Store at 2 - 8 °C.
Shelf life: one year from despatch.

Format
Label:
Biotin
Purification:
Protein G
Buffer System:
PBS
Preservatives:
0.02% sodium azide
Stabilizers:
0.1% bovine serum albumin
State:
Liquid 0.2 µm filtered Ig fraction
Species Reactivity
Species reactivity (tested):
Human
Specificity
Specificity:
This antibody recognizes human TLR2 (CD282).

Accessory Products

  • LinkedIn