discontinued

NB100-78202 TNF- alpha antibody

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0.1 mg / €340.00

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Rat anti Mouse TNF- alpha MP6-XT22

NB100-78202

Product Description for TNF- alpha

Rat anti Mouse TNF- alpha MP6-XT22.
Presentation: FITC
Product is tested for Immunocytochemistry/Immunofluorescence, Flow Cytometry.

Properties for TNF- alpha

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms DIF, MCF
Presentation FITC
Reactivity Ms
Applications F, ICC/IF
Clonality Monoclonal
Clone MP6-XT22
Host Rat
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
E. coli-expressed, recombinant mouse TNF- alpha
Isotype control SM25F, SM25FX
Application Immunocytochemistry, flow cytometry / FACS analysis
Background TNF- alpha is secreted by macrophages, monocytes, neutrophils, T-cells (principally CD4+), and NK-cells. Many transformed cell lines also secrete TNF- alpha. Monomeric mouse TNF- alpha is 156 amino acid protein (N-glycosylated) with a reported molecular weight of 17.5 kD protein. TNF- alpha forms multimeric complexes; stable trimers are most common in solution. A 26 kD membrane form of TNF- alpha has also been described. TNF- alpha binding to surface receptors elicits a wide array of biologic activities including: cytolysis and cytostasis of many tumor cell lines in vitro, hemorraghic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils. The MP6-XT22 antibody can neutralize the bioactivity of natural or recombinant TNF- alpha.
General Readings
  1. Fitzgerald, K., et al., Eds. 2001. The Cytokine FactsBook. Academic Press, San Diego. 2. Beutler, B., et al., 1988. Annu. Rev. Biochem. 57:505. 3. Beutler, B., et al., 1989. Annu. Rev. Immunol. 7:625.
Storage Store at 4C. Do not freeze.
Format
Label:
FITC
Purification:
Immunogen affinity purified
Buffer System:
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Purity:
Immunogen affinity purified
Specificity
Species:
Mouse.

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