NB120-3190 TNF receptor like 2 antibody

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Mouse anti Human TNF receptor like 2 122


Product Description for TNF receptor like 2

Mouse anti Human TNF receptor like 2 122.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Flow Cytometry.

Properties for TNF receptor like 2

Product Category Primary Antibodies
Quantity 0.5 ml
Presentation Purified
Reactivity Hu
Applications F, ICC/IF
Clonality Monoclonal
Clone 122
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Recombinant full length protein (Human).
Isotype control AM03095PU-N, SM10P (for use in human samples)
Background TNF receptor like 2 (TR2) (also known as herpes virus entry mediator (HVEM)) is expressed in multiple human tissues and cell lines and shows a constitutive and relatively high expression in peripheral T and B lymphocytes, and monocytes. It is a member of TNF receptor family. TR2 / HVEM is a receptor for herpes virus. It also acts as a receptor for LIGHT (also known as HVEM ligand), a member of TNF family. TR2 protein inhibits a mixed lymphocyte reaction-mediated proliferation suggesting that the receptor and / or its ligand play a role in T cell stimulation.
General Readings General / background references:Mauri DN et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity 8:21-30 (1998). PubMed PMID: 9462508
Zhai Y et al. LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer. J Clin Invest 102:1142-51 (1998). PubMed PMID: 9739048
Kwon BS et al. A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. J Biol Chem 272:14272-6 (1997). PubMed PMID: 9162061
Montgomery RI et al. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 87:427-36 (1996). PubMed PMID: 8898196
Protein G purified
Buffer System:
10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Protein G purified
Cross-reacts with Human.Not yet tested in other species.

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