AP55705PU-N TNK2 / ACK1 pTyr284 antibody

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0.1 mg / €300.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse TNK2 / ACK1

AP55705PU-N

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Product Description for TNK2 / ACK1

Rabbit anti Human, Mouse TNK2 / ACK1.
Properties: pTyr284
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Paraffin Sections, Western blot / Immunoblot.

Properties for TNK2 / ACK1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Activated CDC42 kinase 1
Presentation Aff - Purified
Reactivity Hu, Ms
Applications ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Molecular weight 120 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q07912
Immunogen:
Peptide sequence around phosphorylation site of tyrosine 284 (D-H-Y(p)-V-M) derived from Human ACK1 (KLH-conjugated)
GeneID:
10188
Property pTyr284
Application Western blot: 1:500~1:1000.
Immunohistochemistry on paraffin sections: 1:50~1:100.
Immunofluorescence: 1:100~1:200.
Background Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes.
Concentration 1.0 mg/ml
General Readings
  1. Manser E, Leung T, Salihuddin H, Tan L, Lim L. A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. Nature. 1993 May 27;363(6427):364-7. PubMed PMID: 8497321.
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. PubMed PMID: 14702039.
  3. Eisenmann KM, McCarthy JB, Simpson MA, Keely PJ, Guan JL, Tachibana K, et al. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. Nat Cell Biol. 1999 Dec;1(8):507-13. PubMed PMID: 10587647.
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography using epitope-specific peptide
Buffer System:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
State:
Liquid Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Mouse
Specificity
Specificity:
The antibody detects endogenous levels of ACK1 only when phosphorylated at tyrosine 284.

Accessory Products

Proteins and/or Positive Controls

Proteins for TNK2 / ACK1 (7 products)

Catalog No. Species Pres. Purity   Source  

TNK2 / ACK1

TNK2 / ACK1 Human Purified
  Abnova Taiwan Corp.

TNK2 / ACK1

TNK2 / ACK1 Human Purified
  Abnova Taiwan Corp.

TNK2 / ACK1

TNK2 / ACK1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

TNK2 / ACK1

TNK2 / ACK1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

TNK2 / ACK1

TNK2 / ACK1 Human
  Abnova Taiwan Corp.

TNK2 / ACK1

TNK2 / ACK1 Human
  Abnova Taiwan Corp.

TNK2 / ACK1

TNK2 / ACK1 Human
  Abnova Taiwan Corp.

Positive controls for TNK2 / ACK1 (1 products)

Catalog No. Species Pres. Purity   Source  

TNK2 / ACK1 Lysate(Denatured)

TNK2 / ACK1 Lysate(Denatured)
  Abnova Taiwan Corp.
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