discontinued

AP00959PU-N Toxic Shock Syndrome Toxin (TSST) antibody

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Search for all "Toxic Shock Syndrome Toxin (TSST)"

1 mg / €570.00

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Sheep anti Toxic Shock Syndrome Toxin (TSST)

AP00959PU-N

Product Description for Toxic Shock Syndrome Toxin (TSST)

Sheep anti Toxic Shock Syndrome Toxin (TSST).
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay.

Properties for Toxic Shock Syndrome Toxin (TSST)

Product Category Primary Antibodies
Quantity 1 mg
Presentation Aff - Purified
Applications E
Clonality Polyclonal
Host Sheep
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Toxic Shock Syndrome Toxin (TSST)
Application ELISA.
Background

Toxic shock syndrome toxin (TSST) is a superantigen with a size of 22KDa produced by 5 to 25% of Staphylococcus aureus isolates. It causes toxic shock syndrome (TSS) by stimulating the release of large amounts of interleukin-1, interleukin-2 and tumour necrosis factor. This bacterium strain that produces the TSST-1 can be found in any area of the body, but live mostly in the vagina of infected women. TSST-1 is a protein encoded by the tstH gene, which is part of the mobile genetic element staphylococcal pathogenicity island. The toxin is produced in the greatest volumes during the post-exponential phase of growth, which is similar among pyrogenic toxin superantigens, also known as PTSAgs. TSST-1 binds primarily to the alpha-chain of class II MHC exclusively through a low-affinity (or generic) binding site on the SAG N-terminal domain. This is opposed to other super antigens (SAGs) such as DEA and SEE, that bind to class II MHC through the low-affinity site, and to the beta-chain through a high-affinity site.  A superantigen such as TSST-1 stimulates human T cells that express VB 2, which may represent 5-30% of all host T cells. PTSAgs induce the VB-specific expansion of both CD4 and CD8- subsets of T Lymphocytes.

Concentration 1,0 mg/ml (prior to lyophilization)
General Readings Dinges, M. M., P. M. Orwin, et al. (2000). "Exotoxins of Staphylococcus aureus." Clinical Microbiology Reviews 13(1): 16-34.
John McCormick, Jeremy M. Yarwood, and Patrick M. Schlievert. (2001). "Toxic Shock Syndrome and Bacterial Superantigens: An Update". Annual Review of Microbiology 55: 77-104.
Storage Prior to reconstitution store at 2-8°C.
Following reconstitution store the antibody at -80°C.
If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Toxin specific immunoaffinity column
Buffer System:
0.01M phosphate, pH 7.4 containing 0.9% Sodium chloride
State:
Lyophilized purified Ig
Aff - Purified
Reconstitution:
Restore with 1ml deionized water
Specificity
Specificity:
This antibody is specific to Toxic Shock Syndrome Toxin (TSST). Minimal cross-reactivity with staphylococcal enterotoxins A through E.

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