AP00959PU-N Toxic Shock Syndrome Toxin (TSST) antibody

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Sheep anti Toxic Shock Syndrome Toxin (TSST)


Product Description for Toxic Shock Syndrome Toxin (TSST)

Sheep anti Toxic Shock Syndrome Toxin (TSST).
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay.

Properties for Toxic Shock Syndrome Toxin (TSST)

Product Category Primary Antibodies
Quantity 1 mg
Presentation Aff - Purified
Applications E
Clonality Polyclonal
Host Sheep
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Toxic Shock Syndrome Toxin (TSST)
Application ELISA.

Toxic shock syndrome toxin (TSST) is a superantigen with a size of 22KDa produced by 5 to 25% of Staphylococcus aureus isolates. It causes toxic shock syndrome (TSS) by stimulating the release of large amounts of interleukin-1, interleukin-2 and tumour necrosis factor. This bacterium strain that produces the TSST-1 can be found in any area of the body, but live mostly in the vagina of infected women. TSST-1 is a protein encoded by the tstH gene, which is part of the mobile genetic element staphylococcal pathogenicity island. The toxin is produced in the greatest volumes during the post-exponential phase of growth, which is similar among pyrogenic toxin superantigens, also known as PTSAgs. TSST-1 binds primarily to the alpha-chain of class II MHC exclusively through a low-affinity (or generic) binding site on the SAG N-terminal domain. This is opposed to other super antigens (SAGs) such as DEA and SEE, that bind to class II MHC through the low-affinity site, and to the beta-chain through a high-affinity site.  A superantigen such as TSST-1 stimulates human T cells that express VB 2, which may represent 5-30% of all host T cells. PTSAgs induce the VB-specific expansion of both CD4 and CD8- subsets of T Lymphocytes.

Concentration 1,0 mg/ml (prior to lyophilization)
General Readings Dinges, M. M., P. M. Orwin, et al. (2000). "Exotoxins of Staphylococcus aureus." Clinical Microbiology Reviews 13(1): 16-34.
John McCormick, Jeremy M. Yarwood, and Patrick M. Schlievert. (2001). "Toxic Shock Syndrome and Bacterial Superantigens: An Update". Annual Review of Microbiology 55: 77-104.
Storage Prior to reconstitution store at 2-8°C.
Following reconstitution store the antibody at -80°C.
If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Toxin specific immunoaffinity column
Buffer System:
0.01M phosphate, pH 7.4 containing 0.9% Sodium chloride
Lyophilized purified Ig
Aff - Purified
Restore with 1ml deionized water
This antibody is specific to Toxic Shock Syndrome Toxin (TSST). Minimal cross-reactivity with staphylococcal enterotoxins A through E.

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