TA326878 Transglutaminase-2 (TGM2) antibody

Rabbit anti-TGM2 Polyclonal Antibody

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0.1 mg / €335.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Mouse, Rat Transglutaminase-2 (TGM2)

Product Description for Transglutaminase-2 (TGM2)

Rabbit anti Human, Mouse, Rat Transglutaminase-2 (TGM2).
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for Transglutaminase-2 (TGM2)

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Protein-glutamine gamma-glutamyltransferase 2, TGase C, TGase-H, Tissue transglutaminase
Presentation Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P21980-2
Immunogen:
Recombinant protein of human TGM2.
GeneID:
7052
Application WB: 1:500-1:2000; IHC: 1:50-1:200
Background Transglutamise 2 (TGM2) is a calcium-dependent enzyme that cross-links both cytosolic and extracellular matrix proteins by catalyzing the formation of bonds between lysine and glutamine residues. This bifunctiol enzyme also has intrinsic GTPase activity, and it has been suggested that regulation of the transamidase activity might be regulated through a G-protein coupled receptor-sigling pathway. In cross-linking peptides, TGM2 helps to regulate cytoskeletal structure, cell migration, apoptosis and cell-matrix adhesion. In addition, the enzyme plays an important role in wound healing and the immune response. TGM2 has exhibited kise activity in vitro, with insulin-like growth factor-binding protein-3 (IGFBP-3) as one possible substrate. This widely expressed protein is localized to the cytosol and nucleus, but has also been isolated from the cell surface and extracellular matrix. Because of its interaction with a number of different substrates, and its role in the response to injury, TGM2 has been associated with the pathology of a number of human disorders. It has long been recognized as the major autoantigen in celiac disease; altered TGM2 expression or activity may be associated with Alzheimer disease, Huntington disease, arteriosclerosis, diabetes, and numerous forms of cancer.
Format
Purification:
Affinity purification
Buffer System:
Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
State:
Purified

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