discontinued

NB100-77952 TREM-1 antibody

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0.25 mg / €310.00

Quick Overview

Mouse anti Human TREM-1 TREM-26

Product Description for TREM-1

Mouse anti Human TREM-1 TREM-26.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot, Flow Cytometry.

Properties for TREM-1

Product Category Primary Antibodies
Quantity 0.25 mg
Presentation Aff - Purified
Reactivity Hu
Applications F, WB
Clonality Monoclonal
Clone TREM-26
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Recombinant human TREM-1
Application flow cytometry / FACS analysis, Western Blot
Background TREM-1 is a 30 kD glycoprotein also known as triggering receptor expressed on myeloid cells 1, and triggering receptor expressed on monocytes 1. It is a Type I membrane protein that contains an immunoglobulin-like V-type domain. Alternatively spliced protein variant may be secreted. TREM-1 is highly expressed on peripheral blood myeloid cells (particularly mature monocytes and granulocytes); TREM-1 expression can be further upregulated by bacteria, fungi and lipopolysaccharide. TREM-1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines. TREM-1 is thought to amplify inflammatory responses to fungal and bacterial infections and potentiate septic shock. This antibody has been shown to be useful for flow cytometry and activation of monocytes and granulocytes.
General Readings
  1. Bouchon, A., et al., 2001. Nature 410:1103.2. Bouchon, A., et al., 2000. J. Immunol. 164:4991.3. Gingras, M.-C., et al., 2002. Mol. Immunol. 38:817.
Storage Store at 4C. Do not freeze.
Format
Purification:
Immunogen affinity purified
Buffer System:
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Species:
Human.

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