NB100-55776 TRF2 antibody

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Mouse anti Human TRF2 4A794.15


Product Description for TRF2

Mouse anti Human TRF2 4A794.15.
Presentation: Biotin
Product is tested for Enzyme Immunoassay.

Properties for TRF2

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Biotin
Reactivity Hu
Applications E
Clonality Monoclonal
Clone 4A794.15
Host Mouse
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Baculovirus expressed whole length TRF2 protein was used for immunizing mice and splenocytes used to generate the hybridoma clone.
Background TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length (1). TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes (1). TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini (2). The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells (2). Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types (3)
Storage Store at 4C. Do not freeze.
Buffer System:
PBS containing 0.02% sodium azide. Sodium azide is highly toxic.
Human Not yet tested in other species.

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