TA328906 TrkB antibody

Rabbit polyclonal Anti-TrkB (extracellular)

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0.2 ml / €585.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse, Rat TrkB

TA328906

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Product Description for TrkB

Rabbit anti Human, Mouse, Rat TrkB.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for TrkB

Product Category Primary Antibodies
Target Category
Quantity 0.2 ml
Synonyms BDNF/NT-3 growth factors receptor, GP145-TrkB, NTRK2, Neurotrophic tyrosine kinase receptor type 2, TRKB, TrkB tyrosine kinase
Presentation Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q63604
Immunogen:
Peptide (C)RLEPNSIDPENITE, corresponding to amino acid residues 57-70 of rat TrkB . Extracellular domain.
GeneID:
25054
Application WB: 1:200-1:2000; IHC: 1:100-1:3
000; FC: 1:50-1:600;
Background BDNF and NT-4 belong to the neurotrophin family which also includes NGF and NT-3. These neurotrophins bind two groups of receptors. The p75NTR receptor is common to all four neurotrophins and is a member of the tumor necrosis factor receptor family. The tropomyosin-related kise (Trk) receptors are receptor tyrosine kises (RTKs) and three receptors form this family: TrkA, TrkB, and TrkC.As mentioned above, the p75NTR receptor binds to all neurotrophins with similar affinities while the Trk receptors are the ones to display the selectivity for the neurotrophins. TrkA is activated by NGF binding, TrkB by that of BDNF and NT-4, while TrkC is stimulated by the binding of NT-3.All three Trk receptors are highly expressed in the mammalian brain in very distinct regions and are also expressed in the peripheral nervous system.Cholinergic neurons in the basal forebrain exclusively express TrkA, while TrkB and TrkC are highly expressed in the hippocampus. Motor and sensory neurons in the peripheral nervous system express Trk receptors. Interestingly, Trk receptors are not essential for development, but knockout mice die shortly after birth. Indeed, TrkB-deficient mice demonstrate a significant decrease in motor neurons and syptogenesis.Trk receptors have many motifs in the extracellular region, including cell-adhesion domains, three tandem leucine rich motifs flanked by two clusters of cysteines. In the membrane proximal region of the receptor there are also two immunoglobulin-like domains. The binding of neurotrophins to Trk receptors promotes receptor dimerization resulting in kise activation. Activated Trk receptors then phosphorylate a cascade of sigling molecules including the Ras/ERK, PI3K/Akt pathways and PLC-g1. Activated Trk receptors also create interl docking sites for other sigling adaptor proteins to bind to. Splice variants of TrkA, TrkB and TrkC have been observed. These splice isoforms are mainly affected in the tyrosine kise domain of the receptor lying in the cytoplasm. Endocytosis is an important sigling trait of Trk receptors.Following neurotrophin binding to the Trk receptor, the receptor complex is then interlized via endocytosis in order to termite sigling. However, in the axol compartment of neurons the interlization process of the neurotrophin complexed to the receptor is part of the sigling process and is important for activating transcription processes in the nucleus.
Format
Purification:
Affinity purified on immobilized antigen.
Buffer System:
Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
State:
Purified

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