discontinued

AP09360PU-N TrkCT1 antibody

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0.1 mg / €440.00

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Rabbit anti Human, Mouse, Rat TrkCT1

AP09360PU-N

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Product Description for TrkCT1

Rabbit anti Human, Mouse, Rat TrkCT1.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Immunoprecipitation, Western blot / Immunoblot.

Properties for TrkCT1

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms GP145-TrkC, NT-3 growth factor receptor, NTRK3, Trk-C
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, IP, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide corresponding to amino acids near the carboxyl terminus of mouse TrkCT1 protein
Application ELISA: 1/5,000 - 1/20,000.
Western Blot: 1/1,000 - 1/10,000.
Immunoprecipitation: 1 µg.
Background TrkCT1, also named neurotrophic tyrosine kinase receptor type 3 (Ntrk3) non-catalytic isoform 2, is a non-catalytic isoform of TrkC, the high affinity receptor for Neurotrophin-3 (NT-3). This isoform lacks the kinase domain that is responsible for signaling by the full-length isoform. TrkCT1 is the product of an alternative splicing of Ntrk3 that leaves the extracellular and transmembrane domains intact but includes a shorter intracellular domain encoded by exons 13b and 14b. Recent studies indicate that the short cytoplasmic tail binds the scaffold protein Tamalin in a ligand-dependent manner and further activates the Arf6–Rac1 signaling pathway (Esteban et al., 2006).
Concentration 1.53 mg/ml (by UV absorbance at 280 nm)
General Readings
  1. Esteban PF, Yoon HY, Becker J, Dorsey SG, Caprari P, Palko ME, et al. A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin. J Cell Biol. 2006 Apr 24;173(2):291-9. PubMed PMID: 16636148. (Free PMC Article available, 7 images available)
  2. Palko ME, Coppola V, Tessarollo L. Evidence for a role of truncated trkC receptor isoforms in mouse development. J Neurosci. 1999 Jan 15;19(2):775-82. PubMed PMID: 9880597.
  3. Menn B, Timsit S, Calothy G, Lamballe F. Differential expression of TrkC catalytic and noncatalytic isoforms suggests that they act independently or in association. J Comp Neurol. 1998 Nov 9;401(1):47-64. PubMed PMID: 9802700.
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography
Buffer System:
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01% (w/v) Sodium Azide
State:
Liquid purified Ig
Aff - Purified
Species Reactivity
Species reactivity (expected):
Human, Rat.
Species reactivity (tested):
Mouse.
Specificity
Specificity:
This antibody is directed against TrkCT1 protein.

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