TA319458 TrkCT1 antibody

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0.1 mg / €325.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Mouse, Rat TrkCT1


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  • TA319458
  • TA319458

Product Description for TrkCT1

Rabbit anti Human, Mouse, Rat TrkCT1.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Immunoprecipitation, Western blot / Immunoblot.

Properties for TrkCT1

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms GP145-TrkC, NT-3 growth factor receptor, NTRK3, Trk-C
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, IP, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Synthetic peptide corresponding to amino acids near the carboxyl terminus of mouse TrkCT1 protein
Application ELISA: 1/5,000 - 1/20,000.
Western Blot: 1/1,000 - 1/10,000.
Immunoprecipitation: 1 µg.
Background TrkCT1, also named neurotrophic tyrosine kinase receptor type 3 (Ntrk3) non-catalytic isoform 2, is a non-catalytic isoform of TrkC, the high affinity receptor for Neurotrophin-3 (NT-3). This isoform lacks the kinase domain that is responsible for signaling by the full-length isoform. TrkCT1 is the product of an alternative splicing of Ntrk3 that leaves the extracellular and transmembrane domains intact but includes a shorter intracellular domain encoded by exons 13b and 14b. Recent studies indicate that the short cytoplasmic tail binds the scaffold protein Tamalin in a ligand-dependent manner and further activates the Arf6–Rac1 signaling pathway (Esteban et al., 2006).
Concentration 1.53 mg/ml (by UV absorbance at 280 nm)
General Readings
  1. Esteban PF, Yoon HY, Becker J, Dorsey SG, Caprari P, Palko ME, et al. A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin. J Cell Biol. 2006 Apr 24;173(2):291-9. PubMed PMID: 16636148. (Free PMC Article available, 7 images available)
  2. Palko ME, Coppola V, Tessarollo L. Evidence for a role of truncated trkC receptor isoforms in mouse development. J Neurosci. 1999 Jan 15;19(2):775-82. PubMed PMID: 9880597.
  3. Menn B, Timsit S, Calothy G, Lamballe F. Differential expression of TrkC catalytic and noncatalytic isoforms suggests that they act independently or in association. J Comp Neurol. 1998 Nov 9;401(1):47-64. PubMed PMID: 9802700.
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinity chromatography
Buffer System:
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01% (w/v) Sodium Azide
Liquid purified Ig
Aff - Purified
Species Reactivity
Species reactivity (expected):
Human, Rat.
Species reactivity (tested):
This antibody is directed against TrkCT1 protein.

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