NB110-74947 TRPC4 antibody

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Rabbit anti Mouse, Rat TRPC4


Product Description for TRPC4

Rabbit anti Mouse, Rat TRPC4.
Presentation: Serum

Properties for TRPC4

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Serum
Reactivity Ms, Rt
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

A synthetic peptide as a part of rat (and isoforms: alpha, beta, beta-2, theta, iota, kappa) mouse, human (and isoforms: CRA-a, b, c, g, f) TRPC4 (TRP4) conjugated to immunogenic carrier protein was used as the immunogen. The antigen is homologous in may other species as well.
Application immunohistochemistry , Western Blot 1:300 to 1:3000
Background FUNCTION: Thought to form non-selective a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.; SUBUNIT: Isoform alpha but not isoform beta associates with inositol-1,4,5-triphosphate receptor (ITPR). Interacts with NHERF.; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).; - TISSUE SPECIFICITY: Abundantly expressed in brain (hippocampal CA1 pyramidal neurons, dentate gyrus granule cells, and cerebral cortical neurons, and in the septal nuclei and the mitral layer of olfactory bulb). Lower levels are detected in other tissues.; - TISSUE SPECIFICITY: Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.
General Readings
  1. Funayama M, et al. Brain Res. Mol. Brain Res. 43:259-266(1996).
  2. Tang Y, et al. J. Biol. Chem. 275:37559-37564(2000).
  3. Mori Y, et a. NeuroReport 9:507-515(1998).
  4. Petersen C.C.H, et al. Biochem. J. 311:41-44(1995).
  5. Freichel M, et al. Nat. Cell Biol. 3:121-127(2001).
Storage Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material. Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1)
Whole antisera
Buffer System:
Lyophilised in PBS
Whole antisera
Rat, mouse. Other species not yet tested. See also the immunogen.

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