TA328685 TRPM1 / LTRPC1 antibody

Rabbit Polyclonal Anti-Human TRPM1

See related secondary antibodies

Search for all "TRPM1 / LTRPC1"

0.2 ml / €435.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human TRPM1 / LTRPC1

Product Description for TRPM1 / LTRPC1

Rabbit anti Human TRPM1 / LTRPC1.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for TRPM1 / LTRPC1

Product Category Primary Antibodies
Target Category
Quantity 0.2 ml
Synonyms Long transient receptor potential channel 1, MLSN, MLSN1, Melastatin-1, Transient receptor potential cation channel subfamily M member 1
Presentation Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q7Z4N2
Immunogen:
Peptide (C)EEKKVKKEKASTETE, corresponding to amino acid residues 1518-1533 of human TRPM1. Intracellular, C-terminus.
GeneID:
4308
Application WB: 1:200-1:2000
Background The mammalian melastatin-related transient receptor potential (TRPM) is a subfamily of the TRP family. The family was med after the first discovered member melastatin (TRPM1) whose gene was identified in metastatic and benign melanomas. The TRPM family consist of eight members desigted as TRPM1-8 that can be further divided into four pairs: TRPM1 and TRPM3; TRPM2 and TRPM8; TRPM4 and TRPM5; and TRPM6 and TRPM7. The TRPM proteins share structural homology with other members of the TRP superfamily channels; six putative transmembrane domains, and cytoplasmic N-terminus and C-terminus. However, due to their long N-terminus and C-terminus they were also med the long TRP channel family. TRPM channels were suggested to play a role in tumourigenesis, proliferation and differentiation. Recently, TRPM1 was found to be down-regulated in a highly metastatic line. The loss of TRPM1 expression has been reported to be correlated to melanoma aggressiveness. Two altertive splice variants of TRPM1 were reported; short (TRPM1-S) and long (TRPM1-L). The TRPM1-S was described to be expressed at human melanocyte and mainly in metastasic melanoma cell lines. While TRPM1-L is expressed at murine CNS.
Format
Purification:
Affinity purified on immobilized antigen.
Buffer System:
Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
State:
Purified

Accessory Products

Proteins and/or Positive Controls

Positive controls for TRPM1 / LTRPC1 (1 products)

Catalog No. Species Pres. Purity   Source  

TRPM1 overexpression lysate

TRPM1 overexpression lysate
0.1 mg / €480.00
  OriGene Technologies, Inc.
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