discontinued

NB100-98916 TRPV6 / ECAC2 antibody

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0.5 mg / €360.00

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Sheep anti Rabbit TRPV6 / ECAC2

NB100-98916

Product Description for TRPV6 / ECAC2

Sheep anti Rabbit TRPV6 / ECAC2.
Presentation: Purified
Product is tested for Frozen Sections, Paraffin Sections, Western blot / Immunoblot.

Properties for TRPV6 / ECAC2

Product Category Primary Antibodies
Quantity 0.5 mg
Synonyms Transient receptor potential cation channel subfamily V member 6
Presentation Purified
Reactivity Rb
Applications C, P, WB
Clonality Polyclonal
Host Sheep
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q4U456
Immunogen:
A synthetic peptide from the 1t extracellular loop of rabbit TRPV6 conjugated to an immunogenic carrier protein was used as the immunogen.
GeneID:
100009565
Add. information Reconstitute in 0.5 ml of sterile water. Centrifuge to remove any insoluble material. When reconstituting, glycerol (1:1) may be added for an additional stability.
Application immunohistochemistry, Western Blot, Immunohistochemistry and Western Blot., immunohistochemistry, Western Blot 10-50 ug/ml
Background FUNCTION: Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. SUBUNIT: Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5, heterotetramer. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in duodenum, proximal jejunum, cecum, and colon. SIMILARITY: Belongs to the transient receptor family, TrpV subfamily. SIMILARITY: Contains 5 ANK repeats.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Purification:
IgG purified
Buffer System:
No Preservative
Purity:
IgG purified
State:
Purified
Specificity
Specificity:
TRPV6.
Species:
Rabbit
Gene ID 100009565

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