discontinued

GTX26048 TSH Receptor [A10] antibody

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50 µg / €330.00

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Mouse anti Human TSH Receptor [A10] A10

GTX26048

Product Description for TSH Receptor [A10]

Mouse anti Human TSH Receptor [A10] A10.
Presentation: Ascites
Product is tested for Frozen Sections, Enzyme Immunoassay, Immunoprecipitation, Western blot / Immunoblot.

Properties for TSH Receptor [A10]

Product Category Primary Antibodies
Quantity 50 µg
Presentation Ascites
Reactivity Hu
Applications C, E, IP, WB
Clonality Monoclonal
Clone A10
Host Mouse
Isotype IgG2b
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Fusion protein, corresponding to amino acids 22-35 of Human TSH receptor.
Application ELISA, IHC-Fr, IP, WB
Background The TSH receptor, a G-protein coupled seven-transmembrane receptor, is present on the basal surface of thyroid follicular cells. It is involved in regulating thyrocyte cell growth and function by mediating thyroid-stimulating hormone (TSH) action. The TSH receptor is also the target autoantigen in autoimmune thyroid diseases. Autoantibodies to the TSH receptor that stimulate cAMP production in thyrocyte cells, called thyroid stimulating antibodies, are responsible for the hyperthyroidism of Graves' Disease. Another class of autoantibodies that block the binding of TSH to the TSH receptor, thyroid-blocking antibodies, may mediate the hypothyroidism associated with Hashimoto's thyroiditis, primary myxoedema, and neonatal hypothyroidism. Studies indicate that these autoantibodies interact primarily with the extracellular region of the TSH receptor.
Concentration 1.7 mg/ml
Storage Store at 4
Format
Purification:
Ascites
Buffer System:
Preservative: NoneConstituents: PBS
Purity:
Ascites
State:
Ascites
Specificity
Specificity:
Human - Not yet tested in other species

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